Lacret Rodney, Oves-Costales Daniel, Pérez-Victoria Ignacio, de la Cruz Mercedes, Díaz Caridad, Vicente Francisca, Genilloud Olga, Reyes Fernando
a Fundación MEDINA , Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía , Granada , Spain.
Nat Prod Res. 2019 Jan;33(1):66-73. doi: 10.1080/14786419.2018.1434636. Epub 2018 Feb 7.
A new medermycin derivative, MDN-0171 (1), and two known structurally related compounds, medermycin (2) and antibiotic G15-F (3) were isolated from the acetone extract of culture broths of the marine-derived Streptomyces albolongus strain CA-186053. Their structures were determined using a combination of spectroscopic techniques, including 1D and 2D NMR and electrospray-time of flight mass spectrometry (ESI-TOF MS). Compounds 2 and 3 accounted for the antimicrobial activity (against methicillin-resistant Staphylococcus aureus and Escherichia coli) previously detected in the crude extract of this actinomycete.
从海洋来源的白色链霉菌CA-186053菌株培养液的丙酮提取物中分离出一种新的麦地霉素衍生物MDN-0171（1）以及两种结构相关的已知化合物麦地霉素（2）和抗生素G15-F（3）。通过包括一维和二维核磁共振以及电喷雾飞行时间质谱（ESI-TOF MS）在内的多种光谱技术结合来确定它们的结构。化合物2和3是先前在该放线菌粗提物中检测到的抗菌活性（针对耐甲氧西林金黄色葡萄球菌和大肠杆菌）的原因。
