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A phase 1 dose-finding study of intravenous L-citrulline in sickle cell disease: a potential novel therapy for sickle cell pain crisis.

作者信息

Majumdar Suvankar, Tirona Rommel, Mashegu Hafsat, Desai Jagdish, Shannon Neil T, Summar Marshall, Cunningham Gary, Darbari Deepika, Nickel Robert, Campbell Andrew, Barr Frederick E

机构信息

Division of Hematology, Children's National Medical Center, George Washington School of Medicine and Health Sciences, Washington, DC, USA.

Department of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi, USA.

出版信息

Br J Haematol. 2019 Feb;184(4):634-636. doi: 10.1111/bjh.15124. Epub 2018 Feb 7.

DOI:10.1111/bjh.15124
PMID:29411862
Abstract
摘要

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Design of an adaptive randomized clinical trial of intravenous citrulline for sickle cell pain crisis in the emergency department.
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