神经学变化与抑郁症

Neurologic Changes and Depression.

作者信息

Greene Ryan D, Wang Sophia

机构信息

Richard L. Roudebush VAMC, 1481 W. 10th Street, Indianapolis, IN 46202, USA; Department of Pyschiatry, Indiana University School of Medicine, Goodman Campbell Neuroscience Center, 355 W. 16th Street, Indianapolis, IN 46202, USA; Center of Health Innovation and Implementation Science, Center for Translational Science and Innovation, Indianapolis, IN, USA; Sandra Eskenazi Center for Brain Care Innovation, Eskenazi Hospital, Indianapolis, IN, USA.

出版信息

Psychiatr Clin North Am. 2018 Mar;41(1):111-126. doi: 10.1016/j.psc.2017.10.009. Epub 2017 Dec 6.

DOI:10.1016/j.psc.2017.10.009

PMID:29412840

Abstract

This article covers current research on the relationship between depression and cognitive impairment in older adults. First, it approaches the clinical assessment of late-life depression and comorbid cognitive impairment. Cognitive risk factors for suicide are discussed. Research is then provided on neuropsychological changes associated with depression, discussing subjective cognitive impairment, mild cognitive impairment, and dementia profiles. Additionally, literature regarding neuroimaging and biomarker findings in depressed older adults is presented. Finally, therapeutic models for treatment of late-life depression are also discussed, including psychotherapy models, holistic treatments, pharmacologic approaches, and brain-stimulation therapies.

摘要

本文涵盖了关于老年人抑郁症与认知障碍之间关系的当前研究。首先，探讨了老年期抑郁症和共病认知障碍的临床评估。讨论了自杀的认知风险因素。接着提供了与抑郁症相关的神经心理学变化的研究，探讨了主观认知障碍、轻度认知障碍和痴呆症概况。此外，还介绍了有关老年抑郁症患者神经影像学和生物标志物研究结果的文献。最后，还讨论了老年期抑郁症的治疗模式，包括心理治疗模式、整体治疗、药物治疗方法和脑刺激疗法。