Kawanishi H
Eur J Immunol. 1986 Jun;16(6):689-92. doi: 10.1002/eji.1830160617.
A role of IgE in the differentiation of gut-associated mast cells (MC) was determined in vitro in the presence of a T cell product, interleukin 3 (IL3). The presence of both IL3 and IgE induced MC with higher precursor frequency than that of IL3 alone, by up to nearly 4 times, while IgE alone failed to develop the clonal growth of MC. IgE, but not the other isotype-specific immunoglobulins, augmented the proliferation of IL3-induced MC in the presence of IL3. Thus, IgE acts as a cofactor in the growth and/or differentiation of MC.
在T细胞产物白细胞介素3（IL3）存在的情况下，体外确定了IgE在肠道相关肥大细胞（MC）分化中的作用。IL3和IgE共同存在时诱导的MC前体频率比单独使用IL3时高，高达近4倍，而单独的IgE则无法促进MC的克隆生长。在IL3存在的情况下，IgE而非其他同种型特异性免疫球蛋白增强了IL3诱导的MC的增殖。因此，IgE在MC的生长和/或分化中起辅助因子的作用。
