Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China.
College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
J Photochem Photobiol B. 2018 Mar;180:9-16. doi: 10.1016/j.jphotobiol.2018.01.020. Epub 2018 Feb 20.
Recently, copper chalcogenide semiconductors have been reported as new near-infrared (NIR) photothermal agents. However, it is difficult to modify them with recognition molecules, and their photothermal conversion efficiencies are relatively low, making it difficult to achieve the targeted photothermal ablation of cancer cells with a high efficiency. In this study, reduced graphene oxide (rGO) was first coated on the surface of CuSe nanoparticles (NPs) to provide abundant functional groups for the next modification and to increase the photothermal conversion efficiency. Then, doxorubicin (DOX) was loaded and folic acid (FA) molecules were covalently linked onto the surface of CuSe/rGO nanocomposites. The formed DOX@CuSe@rGO-FA nanocomposites were successfully used as chemo-photothermal agents for the targeted killing of cancer cells by utilizing the recognition ability of FA, chemotherapy effect of DOX and photothermal effects of rGO and CuSe NPs. Under the 980-nm NIR laser irradiation, the nanocomposites showed significantly enhanced chemo-photothermal therapy effect, which can be potentially applied in the nanomedicine field.
最近，铜硫属化合物半导体已被报道为新型近红外（NIR）光热剂。然而，它们难以用识别分子进行修饰，且光热转换效率相对较低，难以实现高效靶向光热消融癌细胞。在本研究中，首先在 CuSe 纳米颗粒（NPs）表面包覆还原氧化石墨烯（rGO），为下一步修饰提供丰富的功能基团，并提高光热转换效率。然后，将阿霉素（DOX）负载并将叶酸（FA）分子共价连接到 CuSe/rGO 纳米复合材料表面。形成的 DOX@CuSe@rGO-FA 纳米复合材料成功用作化学-光热剂，利用 FA 的识别能力、DOX 的化疗作用以及 rGO 和 CuSe NPs 的光热效应，靶向杀伤癌细胞。在 980nm NIR 激光照射下，纳米复合材料表现出显著增强的化学-光热治疗效果，有望应用于纳米医学领域。
