重症肌无力患者入住重症监护病房的特征、发生率和结局。

Characteristics, incidence, and outcome of patients admitted to the intensive care unit with myasthenia gravis.

机构信息

Department of Intensive Care, Austin Hospital, Heidelberg, Melbourne, Australia.

Australian and New Zealand Intensive Care Research Centre, Monash University School of Public Health and Preventive Medicine, Alfred Hospital, Commercial Rd, Melbourne, Australia.

出版信息

J Crit Care. 2018 Jun;45:90-94. doi: 10.1016/j.jcrc.2018.01.003. Epub 2018 Jan 7.

DOI:10.1016/j.jcrc.2018.01.003

PMID:29413729

Abstract

BACKGROUND

There are limited data on the characteristics, incidence, and mortality of patients with myasthenia gravis (MG) admitted to the ICU.

AIMS

To study the epidemiology, characteristics and outcome of patients with MG in Australian and New Zealand (ANZ) ICUs over a decade.

METHODS

We performed a retrospective observational, cross sectional study of data from the Australian and New Zealand Intensive Care Society (ANZICS) Adult Patient Database (APD). We collected data on all adult patients admitted with a primary diagnosis of MG to 159 Australian and 19 New Zealand ICUs between January 1, 2005 and December 31, 2015.We extracted detailed relevant data and performed statistical assessment.

RESULTS

We identified 245 patients admitted to ICU with the primary diagnosis of MG, with an incidence increasing from 1 to 2.5 per thousand ICU admissions (P<0.0001) and from 1 to 2.2 per million people (P=0.02). Mean age was 60years with more patients being female (53.7% vs 47.3%) and 91 (37.1%) patients received mechanical ventilation. Hospital mortality occurred in 13 (5.3%) patients with a mortality rate lower than in other ICU patients.

CONCLUSIONS

In ANZ, the ICU and population incidence of MG has increased over the last decade. However, its mortality rate was low.

摘要

背景

关于重症肌无力（MG）患者入住 ICU 的特征、发病率和死亡率，相关数据有限。

目的

研究十年来澳大利亚和新西兰（ANZ）ICU 中 MG 患者的流行病学、特征和结局。

方法

我们对澳大利亚和新西兰重症监护学会（ANZICS）成人患者数据库（APD）中的数据进行了回顾性观察性、横断面研究。我们收集了 2005 年 1 月 1 日至 2015 年 12 月 31 日期间，159 家澳大利亚和 19 家新西兰 ICU 收治的所有成人患者中，以 MG 为主要诊断的患者的详细资料。我们提取了相关数据并进行了统计评估。

结果

我们确定了 245 名因 MG 入住 ICU 的患者，发病率从每千名 ICU 患者 1 例增加到 2.5 例（P<0.0001），从每百万人中 1 例增加到 2.2 例（P=0.02）。平均年龄为 60 岁，女性患者比例更高（53.7%比 47.3%），91 名（37.1%）患者接受了机械通气。13 名（5.3%）患者发生院内死亡，死亡率低于其他 ICU 患者。