Nakatsuji T, Moriya K, Ando A, Inoko H, Tsuji K
Hum Immunol. 1986 Jun;16(2):157-62. doi: 10.1016/0198-8859(86)90044-3.
Three homozygous cell lines with different cellular HLA-D specificities associated with HLA-DR2 including Dw2, Dw12, DB9 displayed structural variation in the products of the DQ locus. Nonglycosylated precursor polypeptides of DQ molecules immunoprecipitated by two-dimensional polyacrylamide gel electrophoresis (2-D gel) revealed distinct differences in the patterns of DQ alpha and DQ beta chains.
三个与HLA-DR2相关的具有不同细胞HLA-D特异性的纯合细胞系,包括Dw2、Dw12、DB9,在DQ基因座产物中表现出结构变异。通过二维聚丙烯酰胺凝胶电泳(2-D凝胶)免疫沉淀的DQ分子的非糖基化前体多肽显示,DQα链和DQβ链的模式存在明显差异。