School of Medicine; Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.
São Lucas Hospital, Neurology Service; Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.
Mult Scler Relat Disord. 2018 Feb;20:154-158. doi: 10.1016/j.msard.2018.01.015. Epub 2018 Jan 31.
The corpus callosum index (CCI) can be easily and reliably obtained from conventional magnetic resonance imaging (MRI) and has been proposed as a possible marker of brain atrophy in MS. However, further validation of its correlation with volumetric measurements is still warranted.
To assess the correlation of the CCI with the corpus callosum volume (CCV), brain and lesion volumes, and level of disability in MS.
Cross-sectional, exploratory study including patients with relapsing-remitting MS. Clinical assessment comprised of physical and cognitive disability scales. MRI parameters included conventional volumetric measurements, the CCI (manual), and the CCV (automated).
Twenty-four patients were included. There was a strong correlation between the CCI and CCV. The CCI correlated strongly with the white matter and lesion volumes, and moderately with the whole brain volume and scores on the Paced Auditory Serial Addition Test and MS Functional Composite. There were no correlations between the CCI and either gray matter volume or scores on the Expanded Disability Status Scale, the 9-Hole Peg Test, or the Timed 25-Foot Walk test.
The findings support the validity of the CCI as an easy-to-obtain marker of brain atrophy, lesion load, and cognitive dysfunction in patients with MS.
胼胝体指数（CCI）可通过常规磁共振成像（MRI）轻松且可靠地获得，被提出作为 MS 脑萎缩的可能标志物。然而，其与体积测量值的相关性仍需进一步验证。
评估 CCI 与胼胝体体积（CCV）、脑和病灶体积以及 MS 残疾程度的相关性。
包括复发缓解型 MS 患者的横断面、探索性研究。临床评估包括身体和认知残疾量表。MRI 参数包括常规体积测量、CCI（手动）和 CCV（自动）。
共纳入 24 例患者。CCI 与 CCV 之间存在强相关性。CCI 与脑白质和病灶体积强烈相关，与全脑体积和 Paced Auditory Serial Addition Test 及 MS 功能综合评分中度相关。CCI 与脑灰质体积或扩展残疾状况量表评分、9 孔钉测试或定时 25 英尺步行测试评分之间无相关性。
研究结果支持 CCI 作为一种简便易行的脑萎缩、病灶负荷和认知功能障碍标志物的有效性，适用于 MS 患者。
