埃及膨润土的化妆品和制药资质及其作为吡喹酮药物载体的适用性。
Cosmetic and pharmaceutical qualifications of Egyptian bentonite and its suitability as drug carrier for Praziquantel drug.
机构信息
Geology Department, Faculty of Science, Assiut University, Egypt.
Geology Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.
出版信息
Eur J Pharm Sci. 2018 Mar 30;115:320-329. doi: 10.1016/j.ejps.2018.01.041.
The aim of this paper is to characterize and evaluate newly discovered bentonite deposits in Egypt for pharmaceutical and cosmetic applications as well as its suitability as carrier for Praziquantel drug. The study was performed for the raw bentonite sample, purified bentonite sample and alkali activated purified bentonite sample. The raw bentonite sample composed mainly of montmorillonite contaminated by little amounts of quartz and calcite, while the purified sample composed of montmorillonite without detected mineral impurities and matches the mineralogical properties of Wyoming bentonite as an international standard. Geochemically, the studied raw and purified samples appear to high purity with a chemical composition close to those of Wyoming bentonite and match the pharmacopeia specifications. The chemical properties in addition to the textural properties of the surface area, porosity, particle size distribution qualify the bentonite products to use as a function in powder, emulsion and creams. Investigation of pharmacopeia properties of pH, sedimentation volume and swelling capacity revealed the suitability of the raw and purified samples for pharmaceutical and cosmetic applications. Moreover, the microbiological tests indicated that the samples free from harmful microbial pathogens. At the optimum conditions of time (240 min), bentonite dose (250 mg) and reaction temperature (60 °C), the obtained encapsulation percentages of Praziquantel drug are 62%, 78.4% and 93.2% for raw bentonite, purified and alkali activated bentonite, respectively. The releasing percentage of the drug using an intestinal buffer at pH 7.4 is more efficient and the maximum obtained values were obtained after 420 min. The obtained releasing values are 71%, 79.2% and 87.4% for raw bentonite, purified bentonite and alkali activated bentonite, respectively.
本文旨在对埃及新发现的膨润土矿床进行特性描述和评估，以将其应用于制药和化妆品领域，并作为载体来负载吡喹酮药物。该研究针对原膨润土样品、纯化膨润土样品和碱激活纯化膨润土样品进行。原膨润土样品主要由蒙脱石组成，同时还含有少量的石英和方解石；而纯化样品则由蒙脱石组成，且未检测到任何矿物杂质，其矿物特性与怀俄明州膨润土这一国际标准相符。从地球化学角度来看，所研究的原矿和纯化矿样品显示出高纯度特征，其化学成分与怀俄明州膨润土相近，符合药典规范。此外，除了比表面积、孔隙率和粒度分布等结构特性外，化学特性也使膨润土产品可用于粉末、乳液和乳膏等产品。对药典规定的 pH 值、沉降体积和膨胀能力等性质的研究表明，原矿和纯化矿样品适用于制药和化妆品应用。此外，微生物测试表明，这些样品不含有害的微生物病原体。在时间（240 分钟）、膨润土剂量（250 毫克）和反应温度（60°C）的最佳条件下，原膨润土、纯化膨润土和碱激活膨润土对吡喹酮药物的包封率分别为 62%、78.4%和 93.2%。在 pH 值为 7.4 的肠缓冲液中，药物的释放百分比更有效，最大释放值在 420 分钟后获得。原膨润土、纯化膨润土和碱激活膨润土的药物释放值分别为 71%、79.2%和 87.4%。
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