Strauss M E, Brandt J
J Clin Exp Neuropsychol. 1986 Jun;8(3):210-8. doi: 10.1080/01688638608401313.
WAIS profiles of patients with Huntington's Disease (HD) differ from those of normal controls (NC). Studies of persons at risk for the disease (AR) have reported profiles with qualitative similarities to those of patients. Discriminant function and hierarchical clustering methods were used to explore the utility of WAIS pattern information for the preclinical identification of HD. A three-variable discriminant function correctly identified 79% of HDs and NCs. It classified 45% of ARs with HDs. However, there were no differences between ARs classified with HDs and those classified with NCs. Cluster analysis failed to isolate patient, risk, and control groups. Although performance patterns change very early in HD, WAIS profiles appear to be of limited value for preclinical identification of the disease.
亨廷顿舞蹈症（HD）患者的韦氏成人智力量表（WAIS）剖面图与正常对照组（NC）不同。对该疾病风险人群（AR）的研究报告称，其剖面图在性质上与患者相似。使用判别函数和层次聚类方法来探索WAIS模式信息在HD临床前诊断中的效用。一个三变量判别函数正确识别了79%的HD患者和NC个体。它将45%的AR个体归类为HD患者。然而，归类为HD患者的AR个体与归类为NC个体的AR个体之间没有差异。聚类分析未能区分患者、风险人群和对照组。尽管HD的表现模式在疾病早期就会发生变化，但WAIS剖面图在该疾病的临床前诊断中似乎价值有限。
