Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Campus-Vienna-Biocenter 1, A-1030 Vienna, Austria.
Department of Pathology, New York Medical Center, New York University, New York, USA.
Curr Opin Immunol. 2018 Apr;51:24-31. doi: 10.1016/j.coi.2018.01.001. Epub 2018 Feb 3.
B-1a cells remain one of the most enigmatic lymphocyte subsets. In this review, we discuss recent advances in our understanding of the development of these cells and their regulation by the transcription factors Bhlhe41 and Arid3a as well as by the RNA-binding protein Lin28b. A large body of literature supports an instructive role of BCR signaling in B-1a cell development and lineage commitment, which is initiated only after signaling from an autoreactive BCR. While both fetal and adult hematopoiesis can generate B-1a cells, the contribution of adult hematopoiesis to the B-1a cell compartment is low under physiological conditions. We discuss several models that can reconcile the instructive role of BCR signaling with this fetal bias in B-1a cell development.
B-1a 细胞仍然是最神秘的淋巴细胞亚群之一。在这篇综述中，我们讨论了最近在理解这些细胞的发育及其转录因子 Bhlhe41 和 Arid3a 以及 RNA 结合蛋白 Lin28b 的调控方面的进展。大量文献支持 BCR 信号在 B-1a 细胞发育和谱系决定中的指导作用，这种作用只有在自身反应性 BCR 信号之后才会被触发。虽然胎儿和成体造血都可以产生 B-1a 细胞，但在生理条件下，成体造血对 B-1a 细胞区室的贡献很低。我们讨论了几个模型，可以将 BCR 信号的指导作用与 B-1a 细胞发育中的这种胎儿偏向相协调。
