The First Affiliated Hospital and Center for Stem Cell and Regenerative Medicine, Department of Basic Medical Sciences, School of Medicine, Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang 310058, China.
The First Affiliated Hospital and Center for Stem Cell and Regenerative Medicine, Department of Basic Medical Sciences, School of Medicine, Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Cell Metab. 2018 Feb 6;27(2):332-338. doi: 10.1016/j.cmet.2018.01.008.
Emerging and seminal studies have shown that cell metabolism influences gene expression by modifying the epigenome, which can regulate stem cell pluripotency, differentiation, and somatic cell reprogramming. Core pluripotency factors and developmental regulators reciprocally control the expression of key metabolism genes and their encoded pathways. Recent technological advances enabling sensitive detection methods during early mammalian development revealed the state-specific and context-dependent coordination of signal transduction, histone modifications, and gene expression in developing, resting, and malnourished embryos. Here, we discuss metabolism as a potential driver of earliest cell fate through its influence on the epigenome and gene expression in embryos and their in vitro surrogate pluripotent stem cells.
新兴的重要研究表明，细胞代谢通过修饰表观基因组来影响基因表达，而表观基因组可以调节干细胞的多能性、分化和体细胞重编程。核心多能性因子和发育调节剂相互控制关键代谢基因及其编码途径的表达。最近的技术进步使人们能够在早期哺乳动物发育过程中使用敏感的检测方法，揭示了信号转导、组蛋白修饰和发育中、静止中和营养不良胚胎中基因表达的状态特异性和上下文依赖性协调。在这里，我们讨论了代谢作为最早的细胞命运的潜在驱动因素，通过其对胚胎及其体外替代多能干细胞中的表观基因组和基因表达的影响。
