Yarom R, Sagher U, Havivi Y, Peled I J, Wexler M R
J Neurol Sci. 1986 May;73(3):279-87. doi: 10.1016/0022-510x(86)90152-8.
Muscle samples from the anterior part of the tongue in 15 patients with Down's syndrome (undergoing partial glossectomy), and 6 post-mortem controls, were examined histochemically. In most cases there was a Type 2 myofiber hypertrophy and preponderance, with frequent type 'grouplet' formation. In four cases examined ultrastructurally, hyperplastic, disorganized and atrophic neuromuscular junctions were seen. These preliminary ultrastructural findings suggest that synaptic morphometry could be a rewarding method of studying neuromuscular deficits in Down's syndrome.
对15名唐氏综合征患者（接受部分舌切除术）舌前部的肌肉样本以及6个尸检对照样本进行了组织化学检查。在大多数情况下，存在2型肌纤维肥大和优势，且频繁形成“小群”类型。在4例进行超微结构检查的病例中，可见神经肌肉接头增生、紊乱和萎缩。这些初步的超微结构发现表明，突触形态测量可能是研究唐氏综合征神经肌肉缺陷的一种有价值的方法。
