Movsesian Matthew, Ahmad Faiyaz, Hirsch Emilio
Department of Internal Medicine/Division of Cardiovascular Medicine, University of Utah, Salt Lake City, UT 841132, USA.
Vascular Biology and Hypertension Branch, Division of Cardiovascular Sciences, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA.
J Cardiovasc Dev Dis. 2018 Feb 6;5(1):10. doi: 10.3390/jcdd5010010.
Isoforms in the PDE3 family of cyclic nucleotide phosphodiesterases have important roles in cyclic nucleotide-mediated signalling in cardiac myocytes. These enzymes are targeted by inhibitors used to increase contractility in patients with heart failure, with a combination of beneficial and adverse effects on clinical outcomes. This review covers relevant aspects of the molecular biology of the isoforms that have been identified in cardiac myocytes; the roles of these enzymes in modulating cAMP-mediated signalling and the processes mediated thereby; and the potential for targeting these enzymes to improve the profile of clinical responses.
环核苷酸磷酸二酯酶PDE3家族的同工型在心肌细胞中环核苷酸介导的信号传导中发挥重要作用。这些酶是用于增加心力衰竭患者心肌收缩力的抑制剂的作用靶点，对临床结局有有益和不良的综合影响。本综述涵盖了在心肌细胞中已鉴定出的同工型的分子生物学相关方面；这些酶在调节cAMP介导的信号传导及其介导的过程中的作用；以及靶向这些酶以改善临床反应情况的潜力。
