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MUC8对气道炎症的影响：是友还是敌？

Effect of MUC8 on Airway Inflammation: A Friend or a Foe?

作者信息

Cha Hee-Jae, Song Kyoung Seob

机构信息

Department of Parasitology and Genetics, Kosin University College of Medicine, 34 Amnam-dong, Seo-gu, Busan 49267, Korea.

Department of Physiology, Kosin University College of Medicine, 34 Amnam-dong, Seo-gu, Busan 49267, Korea.

出版信息

J Clin Med. 2018 Feb 6;7(2):26. doi: 10.3390/jcm7020026.

DOI:10.3390/jcm7020026
PMID:29415487
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5852442/
Abstract

In this review, we compile identifying molecular mechanisms of gene expression and studies characterizing the physiological functions of in the airway and analyzing how altered gene expression in the lung is affected by negative regulators.

摘要

在本综述中，我们汇总了确定基因表达的分子机制以及表征其在气道中的生理功能的研究，并分析了肺中基因表达的改变是如何受到负调控因子影响的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47a2/5852442/1905531a9d05/jcm-07-00026-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47a2/5852442/1addb2c501d7/jcm-07-00026-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47a2/5852442/1905531a9d05/jcm-07-00026-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47a2/5852442/1addb2c501d7/jcm-07-00026-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47a2/5852442/1905531a9d05/jcm-07-00026-g002.jpg

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Cadmium induces mucin 8 expression via Toll-like receptor 4-mediated extracellular signal related kinase 1/2 and p38 mitogen-activated protein kinase in human airway epithelial cells.镉通过Toll样受体4介导的细胞外信号调节激酶1/2和p38丝裂原活化蛋白激酶诱导人气道上皮细胞中粘蛋白8的表达。
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