苯巴比妥与多替拉韦之间潜在的药物相互作用：一例报告。
A potential drug interaction between phenobarbital and dolutegravir: A case report.
作者信息
Hikasa Shinichi, Sawada Akihiro, Seino Hitomi, Shimabukuro Shota, Hideta Kyoko, Uwa Noriko, Higasa Satoshi, Tokugawa Tazuko, Kimura Takeshi
机构信息
Department of Pharmacy, The Hospital of Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan.
Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan.
出版信息
J Infect Chemother. 2018 Jun;24(6):476-478. doi: 10.1016/j.jiac.2017.12.022. Epub 2018 Feb 4.
In this report, we describe a human immunodeficiency virus (HIV)-infected patient in whom changes in phenobarbital (PB) dosage resulted in associated changes in plasma concentrations of dolutegravir (DTG). His plasma concentrations of DTG were 0.934, 0.584, 1.003 and 3.25 μg/mL, respectively, with concomitant daily PB doses of 40, 70, 30 and 0 mg, respectively. This case suggests that PB can lead to a remarkable reduction in the plasma concentration of DTG in a dose-dependent manner.
在本报告中，我们描述了一名感染人类免疫缺陷病毒（HIV）的患者，其苯巴比妥（PB）剂量的变化导致多替拉韦（DTG）血浆浓度发生相应变化。他的DTG血浆浓度分别为0.934、0.584、1.003和3.25μg/mL，同时每日PB剂量分别为40、70、30和0mg。该病例表明，PB可导致DTG血浆浓度以剂量依赖的方式显著降低。
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