Ghoshal Arunangshu, Garmo Hans, Arthur Rhonda, Carroll Paul, Holmberg Lars, Hammar Niklas, Jungner Ingmar, Malmström Håkan, Lambe Mats, Walldius Göran, Van Hemelrijck Mieke
King's College London, School of Cancer and Pharmaceutical Sciences, Translational Oncology and Urology Research, London, UK.
Department of Palliative Medicine, Tata Memorial Hospital, Mumbai, India.
Oncotarget. 2017 Dec 4;9(1):774-782. doi: 10.18632/oncotarget.22891. eCollection 2018 Jan 2.
Chronic inflammation is one of the underlying risks associated with thyroid cancer. We ascertained the association between commonly measured serum biomarkers of inflammation and the risk of thyroid cancer in Swedish Apolipoprotein-related MORtality RISk (AMORIS) study. 226,212 subjects had baseline measurements of C-reactive protein, albumin and haptoglobin. Leukocytes were measured in a subgroup of 63,845 subjects. Associations between quartiles and dichotomized values of inflammatory markers and risk of thyroid cancer were analysed using multivariate Cox proportional hazard models. 202 individuals were diagnosed with thyroid cancer during a mean follow-up of 19.6 years. There was a positive association between lower albumin levels and risk of developing thyroid cancer [Hazard Ratio for albumin ≤ 40 g/L: 1.50 (95% Confidence Interval = 1.04-2.16)]. When stratified by a metabolic score, we observed similar association for albumin with higher HR among those with metabolic score ≥ 1, as compared to those with metabolic score of 0 [HR 1.98 (95% CI = 1.11-3.54) vs 1.17 (95% CI = 0.72-1.89)] ( 0.19). Apart from albumin, none of the serum markers of inflammation studied showed a link with the risk of developing thyroid cancer-suggesting that the role of inflammation may be more complicated and requires assessment of more specialised measurements of inflammation.
慢性炎症是与甲状腺癌相关的潜在风险之一。在瑞典载脂蛋白相关死亡风险（AMORIS）研究中，我们确定了常用的炎症血清生物标志物与甲状腺癌风险之间的关联。226,212名受试者进行了C反应蛋白、白蛋白和触珠蛋白的基线测量。在63,845名受试者的亚组中测量了白细胞。使用多变量Cox比例风险模型分析了炎症标志物四分位数和二分值与甲状腺癌风险之间的关联。在平均19.6年的随访期间，有202人被诊断出患有甲状腺癌。白蛋白水平较低与患甲状腺癌的风险呈正相关[白蛋白≤40 g/L的风险比：1.50（95%置信区间=1.04-2.16）]。按代谢评分分层时，我们观察到代谢评分≥1的人群中白蛋白的关联与代谢评分为0的人群相似，但风险比更高[风险比1.98（95%置信区间=1.11-3.54）对1.17（95%置信区间=0.72-1.89）]（P = 0.19）。除白蛋白外，所研究的炎症血清标志物均未显示与患甲状腺癌的风险有联系，这表明炎症的作用可能更为复杂，需要对更专门的炎症测量进行评估。
