Masih D T, Rubinstein H R, Sotomayor C E, Ferro M E, Riera C M
Mycopathologia. 1986 May;94(2):79-84. doi: 10.1007/BF00437371.
The delayed type hypersensitivity response to human serum albumin (HSA) of rats infected intraperitoneally with 10(7) viable C. neoformans cells, and 7 days after, immunized with human serum albumin was significantly diminished (p less than 0.05) when compared with the response observed in rats immunized with human serum albumin and non infected. The spleen mononuclear cells from suppressed rats transferred to normal syngeneic recipients of the same sex suppress the afferent phase of the response (p less than 0.02) suggesting that cells present in the spleen might be one of the responsible mechanisms for the suppression to non-related antigens in infected animals.
用10⁷个活的新型隐球菌细胞腹腔感染大鼠，7天后用人类血清白蛋白免疫，这些大鼠对人类血清白蛋白的迟发型超敏反应与用人类血清白蛋白免疫且未感染的大鼠相比显著减弱（p<0.05）。将受抑制大鼠的脾单核细胞转移到同性正常同基因受体，会抑制反应的传入阶段（p<0.02），这表明脾中的细胞可能是感染动物对非相关抗原抑制的一种责任机制。
