Effect of serotonin on the dissociation of high-affinity binding of [3H]imipramine in mouse cerebral cortex.

A low concentration of norzimelidine can be used to selectively measure the rate of dissociation of [3H]imipramine from high-affinity binding sites in the mouse cerebral cortex. Serotonin attenuates the dissociation initiated by norzimelidine. There is no difference between the half-time of dissociation in the presence of both serotonin and norzimelidine and that in the presence of serotonin alone. These effects are similar to but much less pronounced than those observed in the platelet.