Kim S S, Reith M E
Neurosci Lett. 1986 Jun 18;67(2):123-8. doi: 10.1016/0304-3940(86)90384-8.
A low concentration of norzimelidine can be used to selectively measure the rate of dissociation of [3H]imipramine from high-affinity binding sites in the mouse cerebral cortex. Serotonin attenuates the dissociation initiated by norzimelidine. There is no difference between the half-time of dissociation in the presence of both serotonin and norzimelidine and that in the presence of serotonin alone. These effects are similar to but much less pronounced than those observed in the platelet.
低浓度的去甲齐美利定可用于选择性测量[3H]丙咪嗪从小鼠大脑皮层高亲和力结合位点的解离速率。血清素可减弱去甲齐美利定引发的解离。同时存在血清素和去甲齐美利定情况下的解离半衰期与仅存在血清素时的解离半衰期并无差异。这些效应与在血小板中观察到的效应相似，但程度要轻得多。
