Pavlík A, Benesová O, Buresová M
Physiol Bohemoslov. 1985;34 Suppl:117-20.
The perinatal brain provides a vulnerable target for many noxious insults that interfere--according to their intensity, specificity and timing--with morphogenetic (cell proliferation, migration, association and programmed cell death) and functiogenetic (axogenesis, dendrogenesis, synaptogenesis and myelination) processes. The disturbance of brain cells and/or disorganization of their connections give rise to structural, biochemical and functional pathology most frequently detected in the form of behavioural deviations. For the study of behavioural teratogenicity of perinatal malnutrition, protein synthesis alteration and glucocorticoid administration--all being also important clinically--metabolic, cytotoxic and receptor-mediated models have been designed. The longitudinal follow--up of morphological, neurochemical, endocrine, reproductive, and behavioural changes proved to be valuable for the elucidation of pathogenetic mechanisms as well as for the evaluation of pharmacological influences preventing maldevelopment of the brain.
围产期大脑是许多有害损伤的脆弱靶点，这些损伤会根据其强度、特异性和时间，干扰形态发生（细胞增殖、迁移、联结和程序性细胞死亡）和功能发生（轴突发生、树突发生、突触发生和髓鞘形成）过程。脑细胞的紊乱和/或其连接的紊乱会导致结构、生化和功能病理学，最常见的表现形式是行为偏差。为了研究围产期营养不良、蛋白质合成改变和糖皮质激素给药的行为致畸性（这些在临床上也很重要），已经设计了代谢、细胞毒性和受体介导的模型。对形态、神经化学、内分泌、生殖和行为变化的纵向随访，被证明对于阐明发病机制以及评估预防大脑发育不良的药理学影响很有价值。
