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来自印度锡叶藤（Tetracera indica Merr.）叶片的一种新的硫酸化黄酮及其他植物成分及其α-葡萄糖苷酶抑制活性。

A new sulphated flavone and other phytoconstituents from the leaves of Tetracera indica Merr. and their alpha-glucosidase inhibitory activity.

作者信息

Alhassan Alhassan Muhammad, Ahmed Qamar Uddin, Latip Jalifah, Shah Syed Adnan Ali

机构信息

a Department of Pharmaceutical Chemistry , Kulliyyah of Pharmacy, International Islamic University Malaysia , Kuantan , Malaysia.

b Faculty of Science and Technology, School of Chemical Sciences and Food Technology , Universiti Kebangsaan Malaysia , Bandar Baru Bangi , Malaysia.

出版信息

Nat Prod Res. 2019 Jan;33(1):1-8. doi: 10.1080/14786419.2018.1437427. Epub 2018 Feb 8.

DOI:10.1080/14786419.2018.1437427
PMID:29417849
Abstract

The bioactivity guided fractionation of Tetracera indica leaves crude ethanolic extract has afforded the isolation and characterization of six compounds including a new natural product viz., 5,7-dihydroxyflavone-O-8-sulphate (1) and five known flavonoids (2-6). The structures of the compounds were elucidated using 1D and 2D NMR and HRESIMS spectroscopic analyses. All the isolated compounds were evaluated for their in vitro inhibitory activity against alpha-glucosidase. Compound 1, 5 and 6 showed strong alpha-glucosidase inhibitory activity, 3 and 4 displayed weak activity while compound 2 was inactive. The interactions of the active compounds with alpha-glucosidase were further investigated using molecular docking to confirm their antidiabetic potential.

摘要

对印度刺蒴麻叶粗乙醇提取物进行生物活性导向分离，已分离并鉴定出六种化合物，包括一种新的天然产物，即5,7 - 二羟基黄酮 - O - 8 - 硫酸盐（1）和五种已知的黄酮类化合物（2 - 6）。通过一维和二维核磁共振以及高分辨电喷雾电离质谱光谱分析阐明了这些化合物的结构。对所有分离出的化合物进行了体外抗α - 葡萄糖苷酶抑制活性评估。化合物1、5和6表现出较强的α - 葡萄糖苷酶抑制活性，3和4表现出较弱的活性，而化合物2无活性。使用分子对接进一步研究了活性化合物与α - 葡萄糖苷酶的相互作用，以确认它们的抗糖尿病潜力。

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