Sperber E S, Romero M T, Bodnar R J
Psychopharmacology (Berl). 1986;89(2):175-6. doi: 10.1007/BF00310624.
The effects of the muscarinic receptor antagonist scopolamine upon analgesia induced by D-ala-D-leu-enkephalin (DADL), beta-endorphin (BEND) and morphine were examined. While scopolamine (10 mg/kg, IP) significantly potentiated the analgesic responses following DADL (40 micrograms, ICV) and morphine (5 mg/kg, SC) on the jump test, it failed to alter significantly BEND (1 microgram, ICV) analgesia.
研究了毒蕈碱受体拮抗剂东莨菪碱对由D-丙氨酰-D-亮氨酰-脑啡肽（DADL）、β-内啡肽（BEND）和吗啡诱导的镇痛作用的影响。在跳跃试验中，东莨菪碱（10毫克/千克，腹腔注射）显著增强了DADL（40微克，脑室内注射）和吗啡（5毫克/千克，皮下注射）后的镇痛反应，但对BEND（1微克，脑室内注射）镇痛作用没有显著改变。
