Fedele L, Vercellini P, Viezzoli T, Ricciardiello O, Zamberletti D
Acta Eur Fertil. 1986 Jan-Feb;17(1):31-7.
In the period January 1981-December 1984, 31 cases of intrauterine adhesions (8 severe, 10 moderate and 13 minimal) were diagnosed at the First Department of Obstetrics and Gynecology, University of Milan. This pathology had altered the menstrual function in 21 subjects and reproductive capacity in 27. Synecholysis was performed at hysteroscopy, followed by application of an IUD in 7 patients and sequential treatment with estrogens and progestins in 22. After treatment 67.7% of the women had normal menstruation, and 40.7% of those wanting a child achieved pregnancy with live birth. Repeat hysterography and hysteroscopy after several months showed complete normalization of the uterine cavity in 62.5% of the women, and persistence of minimal and moderate adhesions in 25% and 12.5% respectively. Dissection with miniature scissors under visual control, followed by application of an IUD and sequential administration of estrogens and progestins seems at present the most effective therapeutic regimen for intrauterine adhesions.
1981年1月至1984年12月期间，米兰大学妇产科第一科室诊断出31例宫腔粘连患者（8例重度、10例中度和13例轻度）。这种病症导致21名患者月经功能改变，27名患者生殖能力受损。在宫腔镜下进行粘连松解术，7例患者术后放置宫内节育器，22例患者采用雌激素和孕激素序贯治疗。治疗后，67.7%的女性月经恢复正常，40.7%有生育意愿的女性成功受孕并分娩。数月后复查子宫输卵管造影和宫腔镜检查显示，62.5%的女性宫腔完全恢复正常，25%和12.5%的女性分别仍存在轻度和中度粘连。目前，在可视控制下用微型剪刀进行粘连分离，随后放置宫内节育器并序贯给予雌激素和孕激素，似乎是治疗宫腔粘连最有效的治疗方案。
