[汉族人群中CDH13基因单核苷酸多态性与代谢综合征的关联]
[Association of single nucleotide polymorphisms of CDH13 gene with metabolic syndrome among ethnic Han Chinese].
作者信息
Li Yiping, Yang Ying, Lu Shuaiyao, Li Xianli, Yang Man, Xiong Yuxin, Tao Wenyu, Wang Xiaoling, Yao Yufeng, Xiao Chunjie
机构信息
Department of Endocrinology and Metabolism, the Second People's Hospital of Yunnan Province, the First Affiliated Hospital of Yunnan University, the Fourth Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650021,China; School of Medicine, Yunnan University, Kunming, Yunnan 650091, China. Email:
出版信息
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2018 Feb 10;35(1):107-111. doi: 10.3760/cma.j.issn.1003-9406.2018.01.025.
OBJECTIVE To assess the association of single nucleotide polymorphisms (SNPs) of the T-cadherin (CDH13) gene with metabolic syndrome (MS) among ethnic Han Chinese.METHODS Genotypes of 6 SNPs(rs11646213, rs12596316, rs3865188, rs12444338, rs12051272, and rs7195409) of the CDH13 gene among 453 patients with MS and 526 controls were determined with a TaqMan method, and their association with MS was assessed. RESULTS For 5 SNPs (rs11646213, rs3865188, rs12444338, rs12051272, and rs7195409), no difference was found in allelic and genotypic frequencies of the CDH13 gene between the two groups. Comparing with rs12596316 (AA+GG) genotype, rs12596316 AG genotype has significantly increased the risk of MS(P = 0.01,OR = 1.38,95%CI: 1.07-1.78), though no association was found between particular alleles of the rs12596316 with MS.There was no difference in the frequencies of rs11646213-rs12596316-rs3865188-rs12444338-rs12051272 haplotype between the two groups(P > 0.05). CONCLUSION No association was found between the five SNPs (rs11646213, rs3865188, rs12444338, rs12051272 and rs7195409) of the CDH13 gene with the MS, while the rs12596316AG genotype of the CDH13 gene is associated with the susceptibility to MS among ethnic Han Chinese.
目的 评估汉族人群中T-钙黏蛋白（CDH13）基因单核苷酸多态性（SNP）与代谢综合征（MS）的相关性。方法 采用TaqMan方法检测453例MS患者和526例对照者CDH13基因的6个SNP（rs11646213、rs12596316、rs3865188、rs12444338、rs12051272和rs7195409）基因型，并评估其与MS的相关性。结果 5个SNP（rs11646213、rs3865188、rs12444338、rs12051272和rs7195409）在两组间的CDH13基因等位基因和基因型频率无差异。与rs12596316（AA+GG）基因型相比，rs12596316 AG基因型显著增加了MS风险（P = 0.01，OR = 1.38，95%CI：1.07-1.78），尽管rs12596316的特定等位基因与MS无关联。两组间rs11646213-rs12596316-rs3865188-rs12444338-rs12051272单倍型频率无差异（P > 0.05）。结论 CDH13基因的5个SNP（rs11646213、rs3865188、rs12444338、rs12051272和rs7195409）与MS无关联，而CDH13基因的rs12596316 AG基因型与汉族人群MS易感性相关。
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