Vargas-Alarcon Gilberto, Martinez-Rodriguez Nancy, Velazquez-Cruz Rafael, Perez-Mendez Oscar, Posadas-Sanchez Rosalinda, Posadas-Romero Carlos, Peña-Duque Marco Antonio, Martinez-Rios Marco Antonio, Ramirez-Fuentes Silvestre, Fragoso Jose Manuel
Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
Department of Research in Community Health, Hospital Infantil de Mexico "Federico Gomez", Mexico City, Mexico.
Immunobiology. 2017 Oct;222(10):973-978. doi: 10.1016/j.imbio.2016.09.004. Epub 2016 Sep 21.
Hypertension is a major public health problem affecting about 30% of the adult population and is associated with an increased risk of developing metabolic and cardiovascular disease. Recent reports have shown that the T-cadherin receptor characteristically expressed on endothelial and vascular smooth muscle cells is involved in hypertension. The aim of the present study was to evaluate the role of cadherin-13 (CDH13) gene polymorphisms as susceptibility markers for hypertension in Mexican population. Six CDH13 polymorphisms (rs11646213, rs11646411, rs6563943, rs3096277, rs3784990 and rs254340) were genotyped by 5' exonuclease TaqMan assays in a group of 644 hypertensive and 765 non-hypertensive individuals. Under co-dominant, recessive, and additive models, the CDH13 T>A (rs11646213) polymorphism was associated with decreased risk of developing hypertension when compared to non-hypertensive individuals (OR=0.61, 95% CI: 0.42-0.89, P=0.019; OR=0.63, 95% CI: 0.46-0.87, P=0.005; OR=0.80, 95% CI: 0.66-0.96, P=0.016, respectively). All models were adjusted by gender, age, body index mass, type II diabetes mellitus, alcohol consumption, dyslipidemia and smoking habit. Linkage disequilibrium analysis showed one haplotype (TCACGG) with decreased frequency in hypertensive when compared to non-hypertensive individuals (OR=0.52, 95% CI: 0.33-0.82, P=0.0053). In summary, our data suggests that the CDH13 T>A (rs11646213) polymorphism is associated with decreased risk of developing hypertension in the Mexican population. In addition, it was possible to distinguish one haplotype associated with decreased risk and two for increased risk of develop hypertension.
高血压是一个主要的公共卫生问题，影响着约30%的成年人口，并且与代谢和心血管疾病发生风险的增加相关。最近的报告显示，在内皮细胞和血管平滑肌细胞上特征性表达的T-钙黏蛋白受体与高血压有关。本研究的目的是评估钙黏蛋白-13（CDH13）基因多态性作为墨西哥人群高血压易感性标志物的作用。通过5'核酸外切酶TaqMan分析对644名高血压患者和765名非高血压个体进行了6种CDH13多态性（rs11646213、rs11646411、rs6563943、rs3096277、rs3784990和rs254340）的基因分型。在共显性、隐性和加性模型下，与非高血压个体相比，CDH13 T>A（rs11646213）多态性与高血压发生风险降低相关（OR=0.61，95%CI：0.42-0.89，P=0.019；OR=0.63，95%CI：0.46-0.87，P=0.005；OR=0.80，95%CI：0.66-0.96，P=0.016）。所有模型均根据性别、年龄、体重指数、II型糖尿病、饮酒、血脂异常和吸烟习惯进行了校正。连锁不平衡分析显示，与非高血压个体相比，一种单倍型（TCACGG）在高血压患者中的频率降低（OR=0.52，95%CI：0.33-0.82，P=0.0053）。总之，我们的数据表明，CDH13 T>A（rs11646213）多态性与墨西哥人群高血压发生风险降低相关。此外，有可能区分出一种与风险降低相关的单倍型和两种与高血压发生风险增加相关的单倍型。
