[牡丹江朝鲜族原发性高血压与钠离子转运体基因多态性的关联]
[Association of sodium ion transporter gene polymorphisms with essential hypertension among ethnic Koreans from Mudanjiang].
作者信息
Shi Jiayi, Zhang Chunjun, Bu Xiaobo, Han Yanlong, Deng Daiqian, Song Jie
机构信息
Department of Biology, Mudanjiang Medical College, Mudanjiang, Heilongjiang 157011, China. Email:
出版信息
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2018 Feb 10;35(1):116-120. doi: 10.3760/cma.j.issn.1003-9406.2018.01.027.
OBJECTIVE To assess the association of SLC12A3 and SCNN1B gene polymorphisms (rs11643718 and rs12447134) with essential hypertension among ethnic Koreans from Mudanjiang, China. METHODS For 204 patients with essential hypertension and 186 healthy controls, the genotypes of rs11643718 and rs12447134 loci were determined with an improved multiplex ligase detection reaction (iMLDR) method. RESULTS Allelic and genotypic frequencies of rs11643718 of SLC12A3 gene are associated with the onset of disease hypertension (P <0.05) as well as systolic blood pressure (P < 0.01, under a recessive model). No association was found between rs12447134 of SCNN1B gene with the onset of disease (P > 0.05) but diastolic blood pressure (P < 0.05, under a recessive model). CONCLUSION The polymorphisms of rs11643718 locus is associated with the susceptibility for essential hypertension among ethnic Koreans from Mudanjiang area and can be used as a predictor for the disease.
目的 评估中国牡丹江朝鲜族人群中SLC12A3和SCNN1B基因多态性（rs11643718和rs12447134）与原发性高血压的相关性。方法 采用改良多重连接酶检测反应（iMLDR）方法，对204例原发性高血压患者和186例健康对照者的rs11643718和rs12447134位点的基因型进行检测。结果 SLC12A3基因rs11643718的等位基因和基因型频率与高血压发病相关（P <0.05），与收缩压也相关（隐性模型下P <0.01）。SCNN1B基因rs12447134与疾病发病无相关性（P >0.05），但与舒张压相关（隐性模型下P <0.05）。结论 rs11643718位点多态性与牡丹江地区朝鲜族人群原发性高血压易感性相关，可作为该病的预测指标。
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