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托珠单抗作为格雷夫斯眼眶病继发视神经病变的一线治疗选择。

Tocilizumab as first treatment option in optic neuropathy secondary to Graves' orbitopathy.

作者信息

Pascual-Camps I, Molina-Pallete R, Bort-Martí M A, Todolí J, España-Gregori E

机构信息

a Department of Ophthalmology , Hospital Universitario y Politécnico La Fe , Valencia , Spain.

b Department of Internal Medicine , Hospital Universitario y Politécnico La Fe , Valencia , Spain.

出版信息

Orbit. 2018 Dec;37(6):450-453. doi: 10.1080/01676830.2018.1435694. Epub 2018 Feb 8.

Abstract

Dysthyroid optic neuropathy (DON) is one of the complications that can affect Graves' orbitopathy (GO) patients. Its prevalence is estimated at less than 5%. It is usually treated with intravenous steroids, radiotherapy or orbital decompression. Tocilizumab has been proposed as a treatment option in cases of GO refractory to steroid treatment, with good clinical results. Our aim is to report the case of a patient with optic neuropathy secondary to GO treated with tocilizumab as primary treatment option.

摘要

甲状腺功能异常性视神经病变(DON)是可影响格雷夫斯眼眶病(GO)患者的并发症之一。其患病率估计低于5%。通常采用静脉注射类固醇、放射治疗或眼眶减压进行治疗。对于类固醇治疗无效的GO病例,已提出将托珠单抗作为一种治疗选择,临床效果良好。我们的目的是报告一例以托珠单抗作为主要治疗选择治疗继发于GO的视神经病变患者的病例。

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