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在肺组织标本中检测到的青石棉、温石棉和铁石棉颗粒的纤维尺寸及长径比。

Fiber dimensions and aspect ratio of crocidolite, chrysotile and amosite particles detected in lung tissue specimens.

作者信息

Pooley F D, Clark N

出版信息

Ann N Y Acad Sci. 1979;330:711-6. doi: 10.1111/j.1749-6632.1979.tb18775.x.

DOI:10.1111/j.1749-6632.1979.tb18775.x
PMID:294215
Abstract

Chrysotile, amosite and crocidolite fibers detected in autopsy tissue specimens from cases of mesothelioma and controls have been characterized by particle length, diameter and aspect ratio using a transmission electron microscope. The pooled information from such specimens reveals that the fibers of each mineral type detected in biological material have very different physical characteristics although in all samples fibers less than 5 microns in length are predominant by number while fibers over 25 microns in length are found very infrequently. Chrysotile fibers on average appear as the shortest fibers with the most fine diameter distribution, amosite fibers are on average the longest with the most coarse diameter distribution, crocidolite fibers on average have dimensions which are intermediate between both chrysotile and amosite. The percentage number of fibers of chrysotile, amosite and crocidolite detected with an aspect ratio less than or equal to 10 were 31.7%, 24.2% and 18.5% respectively.

摘要

利用透射电子显微镜,已根据颗粒长度、直径和长径比,对在间皮瘤病例和对照的尸检组织标本中检测到的温石棉、铁石棉和青石棉纤维进行了表征。来自此类标本的汇总信息显示,在生物材料中检测到的每种矿物类型的纤维具有非常不同的物理特性,尽管在所有样本中,长度小于5微米的纤维在数量上占主导地位,而长度超过25微米的纤维则非常罕见。温石棉纤维平均看起来是最短的纤维,直径分布最细,铁石棉纤维平均是最长的,直径分布最粗,青石棉纤维平均尺寸介于温石棉和铁石棉之间。长径比小于或等于10的温石棉、铁石棉和青石棉纤维的数量百分比分别为31.7%、24.2%和18.5%。

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引用本文的文献

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Fibrogenesis by mineral fibres: an in-vitro study of the roles of the macrophage and fibre length.矿物纤维诱导的纤维化:巨噬细胞和纤维长度作用的体外研究
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