Department of Ophthalmology at Eye & ENT Hospital, Institutes of Brain Science, State Key Laboratory of Medical Neurobiology, Shanghai Key Laboratory of Visual Impairment and Restoration, Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200031, China.
CNS Neurol Disord Drug Targets. 2018;17(4):255-260. doi: 10.2174/1871527317666180202114233.
BACKGROUND & OBJECTIVE: Müller cell is the major type of glial cell in the vertebrate retina. Müller cells express various types of K+ channels, such as inwardly rectifying K+ (Kir) channels, big conductance Ca2+-activated K+ (BKCa) channels, delayed rectifier K+ channels (KDR), and transient A-type K+ channels. These K+ channels play important roles in maintaining physiological functions of Müller cells. Under some retinal pathological conditions, the changed expression and functions of K+ channels may contribute to retinal pathogenesis.
In this article, we reviewed the physiological properties of K+ channels in retinal Müller cells and the functional changes of these channels in retinal disorders.
Müller 细胞是脊椎动物视网膜中的主要胶质细胞类型。Müller 细胞表达多种类型的 K+通道，如内向整流型 K+（Kir）通道、大电导 Ca2+-激活型 K+（BKCa）通道、延迟整流型 K+通道（KDR）和瞬态 A 型 K+通道。这些 K+通道在维持 Müller 细胞的生理功能中发挥重要作用。在一些视网膜病理条件下，K+通道的表达和功能改变可能有助于视网膜发病机制。
本文综述了视网膜 Müller 细胞 K+通道的生理特性以及这些通道在视网膜疾病中的功能变化。
