Uchimura N, Higashi H, Nishi S
Brain Res. 1986 Jun 11;375(2):368-72. doi: 10.1016/0006-8993(86)90760-2.
The effect of dopamine (DA) on the nucleus accumbens neurons in guinea-pig brain slices was studied by intracellular recordings. DA caused a hyperpolarization in 28% of the neurons tested, a depolarization in 11%, and a hyperpolarization followed by a depolarization in 53%. The remaining neurons were unaffected. Analyses of the responses revealed that the DA hyperpolarization was produced by activation of the D-1 receptor and associated with an increase in potassium conductance, whereas the DA depolarization was generated by activation of the D-2 receptor and accompanied by a decrease in potassium conductance. DA uptake inhibitors augmented both the hyperpolarizing and depolarizing responses, while cyclic adenosine monophosphate selectively enhanced the former.
通过细胞内记录研究了多巴胺（DA）对豚鼠脑片伏隔核神经元的影响。DA使28%的受试神经元发生超极化，11%发生去极化，53%先发生超极化后发生去极化。其余神经元未受影响。对这些反应的分析表明，DA超极化是由D-1受体激活产生的，与钾电导增加有关，而DA去极化是由D-2受体激活产生的，伴有钾电导降低。DA摄取抑制剂增强了超极化和去极化反应，而环磷酸腺苷选择性增强了前者。
