Li Heng, Tian Zhufang, Zhang Yong, Yang Qi, Shi Bingyin, Hou Peng, Ji Meiju
Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.
Department of Endocrinology, Xi'an Central Hospital, Xi'an, Shaanxi 710003, P.R. China.
Oncol Lett. 2018 Jan;15(1):1014-1020. doi: 10.3892/ol.2017.7416. Epub 2017 Nov 15.
Change in mitochondrial DNA (mtDNA) copy number has been reported in esophageal squamous cell carcinoma (ESCC). However, its prognostic implication in ESCC remains largely unknown. Using reverse transcription-quantitative PCR assay, the mtDNA copy number was assessed in a cohort of patients with ESCC (n=141) and normal esophageal tissues (n=45), and the association between variable mtDNA levels and clinical outcomes of patients with ESCC were studied. Data revealed that ESCC patients exhibited an increased mtDNA content compared to control subjects. Furthermore, increased mtDNA content was associated with a significantly increased risk of cancer-associated mortality. This molecular event was associated with poorer survival in patients with ESCC, and was an independent predictor of patient survival. Data demonstrated that increased mtDNA content is a common genetic event in ESCC and may be a predictive factor of poor prognosis for ESCC patients.
已有报道称食管鳞状细胞癌（ESCC）中存在线粒体DNA（mtDNA）拷贝数的变化。然而，其在ESCC中的预后意义仍 largely未知。使用逆转录定量PCR检测法，对一组ESCC患者（n = 141）和正常食管组织（n = 45）的mtDNA拷贝数进行了评估，并研究了可变mtDNA水平与ESCC患者临床结局之间的关联。数据显示，与对照受试者相比，ESCC患者的mtDNA含量增加。此外，mtDNA含量增加与癌症相关死亡率显著增加相关。这一分子事件与ESCC患者较差的生存率相关，并且是患者生存的独立预测因子。数据表明，mtDNA含量增加是ESCC中常见的遗传事件，可能是ESCC患者预后不良的预测因素。
