Cheong Jamie, Ooi Khai
Department of Nephrology, Western Health, Footscray, VIC, Australia.
Clin Kidney J. 2018 Feb;11(1):51-53. doi: 10.1093/ckj/sfx072. Epub 2017 Aug 10.
We report a case of rituximab-induced serum sickness in a 50-year-old female with idiopathic membranous nephropathy. Presentation was characterized by a widespread rash 1 week after rituximab administration followed by fever and profound haemodynamic instability, mimicking sepsis. Symptoms resolved over 48 h, although adjunct antibiotics, steroids and inotropes were used. This case is notable for being the first reaction with rituximab for a renal indication as well as the severity of presentation.
我们报告一例50岁患有特发性膜性肾病的女性患者，出现利妥昔单抗诱导的血清病。表现为在使用利妥昔单抗1周后出现广泛皮疹，随后出现发热和严重血流动力学不稳定，类似脓毒症。尽管使用了辅助抗生素、类固醇和血管活性药物，但症状在48小时内缓解。该病例值得注意的是，这是利妥昔单抗首次用于肾脏适应症时出现的反应，且临床表现严重。
