Liew D F, Ng C S, Heng S H, Ratnam S S
Contraception. 1986 Apr;33(4):385-94. doi: 10.1016/0010-7824(86)90101-0.
The metabolic effects of an injectable contraceptive, Depo-provera (medroxyprogesterone acetate), an oral contraceptive pill containing 50 micrograms ethinyl estradiol and 500 micrograms norgestrel and a control group (not on contraceptives) were compared in 3 groups, each comprising 32 women. The subjects were matched for race, age and parity. Mean duration of treatment was 41.7 +/- 18.3 months for Depo-provera and 59.6 +/- 29.0 months for the pill group. Glucose tolerance was impaired in both treatment groups. The combination pill showed more changes in both glucose tolerance and insulin response. Lipid levels remained unchanged in both treatment groups.
在三组中比较了一种注射用避孕药（醋酸甲羟孕酮，即狄波-普维拉）、一种含50微克炔雌醇和500微克炔诺孕酮的口服避孕药以及一个对照组（未使用避孕药）的代谢效应，每组有32名女性。受试者在种族、年龄和胎次方面进行了匹配。狄波-普维拉组的平均治疗时长为41.7±18.3个月，口服避孕药组为59.6±29.0个月。两个治疗组的糖耐量均受损。复方口服避孕药在糖耐量和胰岛素反应方面均出现了更多变化。两个治疗组的血脂水平均保持不变。
