Poppius H, Sovijärvi A R, Tammilehto L
Eur J Respir Dis. 1986 May;68(5):319-25.
To evaluate the preventive effect of inhaled ipratropium powder on low-grade bronchoconstriction elicited by breathing cold air during exercise, we subjected 10 adult patients with mild asthma to four identical treadmill exercise tests. The temperature of inhaled air during exercise was -9 +/- 1 degree C. Sixty minutes before exercise, the patients inhaled either placebo or 0.2, 1, or 2 mg of ipratropium powder according to a cross-over, double-blind arrangement. The mean post-exercise fall from the post-treatment pre-exercise values in the four treatment groups was 14, 14, 16 and 16% for FEV1, and 59, 52, 52 and 55% for SGaw, respectively. We concluded that doses of ipratropium up to 20-50 times higher than those known to have a marked effect on resting bronchomotor tone in clinically stable asthma did not blunt the bronchoconstriction response following exercise with cold air breathing in our patients with mild asthma.
为评估吸入异丙托溴铵粉对运动期间呼吸冷空气引发的轻度支气管收缩的预防效果，我们让10名轻度哮喘成年患者进行了4次相同的跑步机运动测试。运动期间吸入空气的温度为-9±1℃。运动前60分钟，患者根据交叉、双盲安排吸入安慰剂或0.2、1或2毫克异丙托溴铵粉。四个治疗组中，运动后相对于治疗后运动前值，第一秒用力呼气量（FEV1）的平均下降分别为14%、14%、16%和16%，比气道传导率（SGaw）的平均下降分别为59%、52%、52%和55%。我们得出结论，在我们的轻度哮喘患者中，与已知对临床稳定哮喘患者静息支气管运动张力有显著作用的剂量相比，高达20至50倍的异丙托溴铵剂量并不能减弱运动期间呼吸冷空气后的支气管收缩反应。
