光学相干断层扫描引导下亚临床复发性视网膜母细胞瘤的管理
OCT-guided management of subclinical recurrent retinoblastoma.
作者信息
Gaillard Marie-Claire, Houghton Susan, Stathopoulos Christina, Munier Francis L
机构信息
a Department of Ophthalmology, University of Lausanne , Jules-Gonin Eye Hospital, Fondation Asile des Aveugles , Lausanne , Switzerland.
出版信息
Ophthalmic Genet. 2018 Jun;39(3):338-343. doi: 10.1080/13816810.2018.1436183. Epub 2018 Feb 9.
PURPOSE
Retinoblastoma (Rb) tumor recurrence in the papillary or macular region is a threat to life and visual prognosis respectively, making early detection indispensable. This study demonstrates the value of optical coherence tomography (OCT) in the early detection of subclinical tumor recurrence.
METHODS
Since June 2012, hand-held SD-OCT (spectral domain Optical Coherence Tomography) of retro-equatorial foci, the optic head nerve and macula, is systematically performed under anesthesia in children treated and followed for Rb.
RESULTS
Between June 2012 and January 2017, 16 subclinical recurrent tumors in 14 children were detected only by OCT in flat pigmented scars (n = 9), in type 2 regression (n = 3), on the optic nerve head (n = 3), and as secondary retinal seeding (n = 1).
CONCLUSION
OCT has become invaluable in the modern management of Rb. It allows not only early detection of a lesion before any tumor extension towards the macula or optic nerve head, but also the monitoring of the therapeutic response.
目的
视网膜母细胞瘤（Rb）在乳头或黄斑区的肿瘤复发分别对生命和视觉预后构成威胁，因此早期检测必不可少。本研究证明了光学相干断层扫描（OCT）在亚临床肿瘤复发早期检测中的价值。
方法
自2012年6月起，对接受Rb治疗并随访的儿童在麻醉下系统地进行赤道后病灶、视神经乳头和黄斑的手持式SD-OCT（光谱域光学相干断层扫描）检查。
结果
在2012年6月至2017年1月期间，14名儿童中的16个亚临床复发性肿瘤仅通过OCT在扁平色素沉着瘢痕（n = 9）、2型消退（n = 3）、视神经乳头（n = 3）以及作为继发性视网膜播散（n = 1）中检测到。
结论
OCT在Rb的现代管理中已变得至关重要。它不仅能在肿瘤向黄斑或视神经乳头扩展之前早期检测到病变，还能监测治疗反应。
Zotero 插件