Laboratory of Neurogenetics and Neuroinflammation, INSERM UMR1163, Institut Imagine, Paris, France.
Laboratory of Neurogenetics and Neuroinflammation, INSERM UMR1163, Institut Imagine, Paris, France; Paris Descartes University, Sorbonne-Paris-Cité, Institut Imagine, Paris 75015, France; Department of Genetics, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris 75015, France; Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Cell. 2018 Feb 8;172(4):640-642. doi: 10.1016/j.cell.2018.01.023.
Discrimination between viral and self-derived nucleic acid species is crucial in maintaining effective antiviral immunity whilst avoiding autoinflammation. Ahmad et al. and Chung et al. delineate the consequences of MDA5 gain of function and loss of ADAR1 activity, highlighting the blurring of the concept of self and non-self when considering endogenous retroelements.
区分病毒和自身来源的核酸种类对于维持有效的抗病毒免疫而避免自身炎症至关重要。Ahmad 等人和 Chung 等人描述了 MDA5 获得功能和 ADAR1 活性丧失的后果，强调了当考虑内源性逆转录元件时，自我和非自我概念的模糊性。
