Ayad A, Lemouakni S, Tami L, Oulja M, Knouni H, Barkat A
Équipe de recherche en santé et nutrition du couple mère enfant, service de réanimation néonatale, faculté de médecine et de pharmacie, hôpital d'enfants de Rabat, université Mohamed V, Rabat, Maroc.
Équipe de recherche en santé et nutrition du couple mère enfant, service de réanimation néonatale, faculté de médecine et de pharmacie, hôpital d'enfants de Rabat, université Mohamed V, Rabat, Maroc.
J Med Vasc. 2018 Feb;43(1):56-60. doi: 10.1016/j.jdmv.2017.11.007. Epub 2017 Dec 26.
Arterial thrombosis of the newborn is rare and associated with poor prognosis, often attributed to umbilical arterial catheterization. The aortic and spontaneous forms are exceptional. Its severity requires fast and effective treatment. Although therapeutic means are numerous, no consensus has been established to date although thrombolysis and heparin therapy appear to give good results depending on the site and extent of thrombosis. We report a case of extensive thrombosis of the abdominal aorta in a 5-day-old newborn, revealed by acute hypernatremic dehydration. Thrombosis was not related to umbilical catheterization. The diagnosis was confirmed by Doppler ultrasound with discovery during the etiologic assessment of an authentic protein S deficiency. This observation was the occasion for a review of the literature concerning the evolutionary and therapeutic clinical aspects of neonatal arterial thrombosis.
新生儿动脉血栓形成较为罕见，且预后不良，常归因于脐动脉插管。主动脉型和自发性动脉血栓形成则更为罕见。其严重性需要快速有效的治疗。尽管治疗方法众多，但迄今为止尚未达成共识，不过溶栓和肝素治疗似乎根据血栓形成的部位和范围能取得较好效果。我们报告一例5日龄新生儿腹部主动脉广泛血栓形成的病例，该病例由急性高钠血症脱水引发。血栓形成与脐动脉插管无关。通过多普勒超声确诊，在病因评估过程中发现存在真正的蛋白S缺乏。该病例促使我们对有关新生儿动脉血栓形成的临床演变及治疗方面的文献进行了回顾。
