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机器人辅助经阴道骶骨阴道固定术:生殖器裂孔增大的手术复位后的早期术后结果。

Robotic-assisted sacrocolpopexy: early postoperative outcomes after surgical reduction of enlarged genital hiatus.

机构信息

Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics, Gynecology, and Reproductive Sciences, Women's Center for Bladder and Pelvic Health, University of Pittsburgh Medical Center, Pittsburgh, PA.

Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC.

出版信息

Am J Obstet Gynecol. 2018 May;218(5):514.e1-514.e8. doi: 10.1016/j.ajog.2018.01.046. Epub 2018 Feb 6.

Abstract

BACKGROUND

Currently, the decision to perform a concurrent posterior repair/perineoplasty at the time of robotic-assisted sacrocolpopexy is not standardized.

OBJECTIVE

We sought to compare anatomic failure after robotic-assisted sacrocolpopexy among 3 groups of patients categorized by their preoperative and postoperative genital hiatus size.

STUDY DESIGN

We performed a retrospective cohort study of women who underwent robotic-assisted sacrocolpopexy, from January 2013 through September 2016. We defined a wide genital hiatus as ≥4 cm and a normal genital hiatus as <4 cm. We compared 3 groups: (1) wide preoperative and postoperative genital hiatus (persistently wide); (2) wide preoperative and normal postoperative genital hiatus (improved); and (3) normal preoperative and postoperative genital hiatus (stably normal). Our primary outcome was composite anatomic failure defined as either recurrent prolapse in any compartment past the hymen or retreatment for prolapse with either surgery or pessary. Our data were analyzed using 1-way analysis of variance and χ test. Logistic regression was performed to evaluate for independent risk factors for anatomic failure among the 3 groups. P < .05 was considered significant.

RESULTS

Our study population consisted of 452 women with a mean age of 59.3 ± 10.0 years and a mean body mass index of 27.8 ± 5.3 kg/m. Of the women with reported race, 394/447 (88.1%) were white. The genital hiatus groups were distributed as follows: 57 (12.6%) were persistently wide, 296 (65.5%) were improved, and 99 (21.9%) were stably normal. The stably normal group had less advanced preoperative prolapse (stage ≥3) than the other groups (P < .01). A similar percentage of patients among groups had a concomitant posterior repair/perineoplasty (P = .09) with a total of 84 (18.6%) women undergoing this procedure. There was a statistically significant difference in overall composite anatomic failure among the groups (P = .03). There was an increase in failure in the persistently wide group (14.0%) compared to the improved group (5.7%, P = .04) and compared to the stably normal group (4.0%, P = .03). In a logistic regression model, controlling for number of vaginal deliveries and posterior repair/perineoplasty, there was a 5.3-fold increased odds of composite anatomic failure in the persistently wide group (adjusted odds ratio, 5.3; 95% confidence interval, 1.4-19.1; P = .01) compared to the stably normal group. In a subanalysis of failure by compartment, there was an increase in failure of the posterior compartment in the persistently wide group compared to the improved group (8.8% vs 2.0%, P < .01), but not the stably normal group (3.0%, P = .12). There was not a statistically significant difference in failure of the combined apical and anterior compartments among groups (P = .29).

CONCLUSION

Surgical reduction of an enlarged preoperative genital hiatus decreases early composite anatomic failure, after robotic sacrocolpopexy, specifically related to the posterior compartment. Studies investigating the correlation of intraoperative measurement of genital hiatus to postoperative genital hiatus are needed to help clinicians determine who may benefit from a concomitant posterior repair/perineoplasty at the time of robotic-assisted sacrocolpopexy.

摘要

背景

目前,在机器人辅助骶骨阴道固定术时是否同时进行后修补/会阴成形术尚未标准化。

目的

我们旨在比较根据术前和术后生殖器裂孔大小对接受机器人辅助骶骨阴道固定术的患者进行分组后的解剖学失败情况。

研究设计

我们对 2013 年 1 月至 2016 年 9 月接受机器人辅助骶骨阴道固定术的女性进行了回顾性队列研究。我们将宽生殖器裂孔定义为≥4cm,正常生殖器裂孔定义为<4cm。我们将 3 组进行比较:(1)术前和术后生殖器裂孔均宽(持续宽);(2)术前宽而术后生殖器裂孔正常(改善);(3)术前和术后生殖器裂孔均正常(稳定正常)。我们的主要结局是定义为处女膜后任何部位的复发性脱垂或因脱垂而进行手术或使用子宫托治疗的复合解剖学失败。我们使用单因素方差分析和 χ 检验分析数据。进行逻辑回归以评估 3 组中解剖学失败的独立危险因素。P<0.05 被认为有统计学意义。

结果

我们的研究人群由 452 名年龄 59.3±10.0 岁、平均体重指数 27.8±5.3kg/m 的女性组成。在报告种族的女性中,394/447(88.1%)为白人。生殖器裂孔组的分布如下:57 例(12.6%)持续宽,296 例(65.5%)改善,99 例(21.9%)稳定正常。稳定正常组的术前脱垂程度(≥3 期)低于其他组(P<0.01)。各组行同期后修补/会阴成形术的患者比例相似(P=0.09),共有 84 例(18.6%)女性行此手术。各组之间的整体复合解剖学失败存在统计学显著差异(P=0.03)。与改善组(5.7%,P=0.04)和稳定正常组(4.0%,P=0.03)相比,持续宽组的失败率(14.0%)增加。在控制阴道分娩次数和后修补/会阴成形术的逻辑回归模型中,与稳定正常组相比,持续宽组的复合解剖学失败的优势比为 5.3(调整后的优势比,5.3;95%置信区间,1.4-19.1;P=0.01)。在后修补/会阴成形术的亚组分析中,与改善组相比,持续宽组的后腔失败率增加(8.8%比 2.0%,P<0.01),但与稳定正常组相比则无统计学差异(3.0%,P=0.12)。各组之间联合前顶腔失败率无统计学显著差异(P=0.29)。

结论

机器人辅助骶骨阴道固定术后,缩小术前扩大的生殖器裂孔可降低早期复合解剖学失败的风险,特别是与后腔有关。需要研究术中生殖器裂孔测量与术后生殖器裂孔的相关性,以帮助临床医生确定哪些患者可能受益于机器人辅助骶骨阴道固定术时同时进行后修补/会阴成形术。

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