Kim Bum Joon, Lee Sung Ho, Kwun Byung Duk, Kang Hyun Goo, Hong Keun-Sik, Kang Dong-Wha, Kim Jong S, Kwon Sun U
Department of Neurology, Kyung Hee University Hospital, Seoul, Korea.
Department of Neurosurgery, Kyung Hee University Hospital, Seoul, Korea.
World Neurosurg. 2018 Apr;112:e876-e880. doi: 10.1016/j.wneu.2018.01.196. Epub 2018 Feb 7.
Although intracranial aneurysms (IAs) are focal bulges of arterial walls, an uncharacterized predisposing factor that affects cerebral arteries may increase tortuosity of intracranial arteries in patients with IAs.
Subjects who underwent routine health examinations and magnetic resonance angiography at a university hospital health promotion center were enrolled. Age- and sex-matched control subjects were selected from among individuals who did not have IAs. Tortuosity of right and left middle cerebral arteries and basilar artery (BA) was measured. Distant factor [(arc/chord ratio × 100) - 100] was used to estimate tortuosity. Vascular risk factors and intracranial arterial tortuosities were compared between subjects with IAs and control subjects. Independent factors associated with intracranial artery tortuosity were also investigated.
Of 18,954 (1.9%) subjects, 367 exhibited IAs. The prevalence of hypertension (P = 0.01) and current smoking (P = 0.01) were higher in subjects with IAs than in control subjects. The BA tortuosity was greater in subjects with IAs compared with control subjects (9.0 ± 8.1 vs. 5.5 ± 7.2; P < 0.001). In addition to hypertension, smoking, and absence of coronary artery disease, BA tortuosity (P < 0.001) was independently associated with presence of IAs. The presence of IA (P < 0.001) and absence of coronary artery disease (P = 0.002) were independently associated with high BA tortuosity.
Patients with IAs exhibit a more tortuous BA. A predisposing factor weakening the cerebrovasculature in patients with IAs may exist and may manifest as high tortuosity of intracranial arteries.
尽管颅内动脉瘤（IAs）是动脉壁的局灶性膨出，但影响脑动脉的一个未明确的易感因素可能会增加颅内动脉瘤患者颅内动脉的迂曲度。
纳入在大学医院健康促进中心接受常规健康检查和磁共振血管造影的受试者。年龄和性别匹配的对照受试者从没有颅内动脉瘤的个体中选取。测量左右大脑中动脉和基底动脉（BA）的迂曲度。采用远距离因子[（弧/弦比×100）-100]来估计迂曲度。比较颅内动脉瘤患者和对照受试者的血管危险因素及颅内动脉迂曲度。还研究了与颅内动脉迂曲相关的独立因素。
在18954名受试者（1.9%）中，367名有颅内动脉瘤。颅内动脉瘤患者的高血压患病率（P = 0.01）和当前吸烟率（P = 0.01）高于对照受试者。与对照受试者相比，颅内动脉瘤患者的基底动脉迂曲度更大（9.0±8.1对5.5±7.2；P < 0.001）。除高血压、吸烟和无冠状动脉疾病外，基底动脉迂曲度（P < 0.001）与颅内动脉瘤的存在独立相关。颅内动脉瘤的存在（P < 0.001）和无冠状动脉疾病（P = 0.002）与基底动脉高度迂曲独立相关。
颅内动脉瘤患者的基底动脉更为迂曲。颅内动脉瘤患者可能存在一种使脑血管系统减弱的易感因素，可能表现为颅内动脉高度迂曲。
