Department of Food Science and Technology, Keimyung University, Daegu 42601, Republic of Korea; World Institute of Kimchi, Gwangju 61755, Republic of Korea.
Department of Food Science and Technology, Keimyung University, Daegu 42601, Republic of Korea.
Food Chem. 2018 Jun 15;251:51-57. doi: 10.1016/j.foodchem.2018.01.071. Epub 2018 Jan 10.
Turmeric contains curcumin and its analogues, which show anticancer and antiinflammatory effects; however, curcuminoids are lipophilic and are poorly absorbed by the human body. Nanostructured lipid carriers for encapsulating whole turmeric powder were successfully produced by ultrasonication, and their physicochemical properties and stability in simulated gastric and intestinal media were evaluated. The turmeric nanostructured lipid carriers (TNLCs) exhibited a round shape, small diameter (282 ± 7.19 nm), adequate zeta potential (-22.75 ± 1.20 mV), and high encapsulation efficiency (93.3 ± 0.01%). The TNLCs were able to protect the encapsulated curcuminoids under acidic gastric conditions, and effectively released 95 ± 2.51% of the curcuminoids in the simulated intestinal medium, demonstrating their suitability for controlled release. The in vitro bioaccessibility of the encapsulated curcuminoids was 75 ± 1.24%, representing more than a fourfold increase compared to that of free turmeric. Therefore, the proposed TNLCs are a promising delivery system for increasing the bioaccessibility of curcuminoids from turmeric.
姜黄含有姜黄素及其类似物，具有抗癌和抗炎作用；然而，姜黄素类是亲脂性的，人体吸收不良。通过超声成功制备了包封全姜黄粉的纳米结构脂质载体，并对其在模拟胃液和肠液中的理化性质和稳定性进行了评价。姜黄纳米结构脂质载体（TNLCs）呈圆形，粒径小（282±7.19nm），适当的Zeta 电位（-22.75±1.20mV），包封效率高（93.3±0.01%）。TNLCs 能够在酸性胃条件下保护包封的姜黄素类，在模拟肠液中有效释放 95±2.51%的姜黄素类，表明其适合控制释放。包封姜黄素类的体外生物利用度为 75±1.24%，与游离姜黄相比增加了四倍以上。因此，所提出的 TNLCs 是一种有前途的递送系统，可提高姜黄中姜黄素类的生物利用度。
