Department of Food Science and Technology, Sejong University, Seoul, Republic of Korea.
J Agric Food Chem. 2013 Feb 27;61(8):1878-83. doi: 10.1021/jf305143k. Epub 2013 Feb 15.
To increase the oral bioavailability of curcumin and genistein, we fabricated nanostructured lipid carriers (NLCs), and the impact of these carriers on bioaccessibility of curcumin and genistein was studied. Entrapment efficiency was more than 75% for curcumin and/or genistein-loaded NLCs. Solubility of curcumin and/or genistein in simulated intestinal medium (SIM) was >75% after encapsulating within NLCs which otherwise was <20%. Both curcumin and genistein have shown good stability (≥85%) in SIM and simulated gastric medium (SGM) up to 6 h. Coloading of curcumin and genistein had no adverse effect on solubility and stability of each molecule. Instead, coloading increased loading efficiency and the cell growth inhibition in prostate cancer cells. Collectively, these results have shown that coloaded lipid based carriers are promising vehicles for oral delivery of poorly bioaccessible molecules like curcumin and genistein.
为了提高姜黄素和染料木黄酮的口服生物利用度，我们制备了纳米结构脂质载体（NLC），并研究了这些载体对姜黄素和染料木黄酮生物利用度的影响。载有姜黄素和/或染料木黄酮的 NLC 的包封效率均超过 75%。将姜黄素和/或染料木黄酮封装在 NLC 内后，其在模拟肠液（SIM）中的溶解度>75%，而在 NLC 之外的溶解度<20%。姜黄素和染料木黄酮在 SIM 和模拟胃液（SGM）中均表现出良好的稳定性（≥85%），长达 6 小时。姜黄素和染料木黄酮的共载没有对每种分子的溶解度和稳定性产生不利影响。相反，共载增加了载药量并抑制了前列腺癌细胞的生长。总的来说，这些结果表明，共载脂质载体是提高生物利用度差的分子（如姜黄素和染料木黄酮）口服递送的有前途的载体。
