Radkey Denise I, Hardie Robert J, Smith Lesley J
University of Wisconsin Veterinary Care, Section of Anesthesia and Pain Management, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA.
Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA.
Vet Anaesth Analg. 2018 May;45(3):241-249. doi: 10.1016/j.vaa.2017.08.014. Epub 2018 Feb 3.
To compare the effects of alfaxalone and propofol, with and without acepromazine and butorphanol followed by doxapram, on laryngeal motion and quality of laryngeal examination in dogs.
Randomized, crossover, blinded study.
Ten female Beagle dogs, aged 11-13 months and weighing 7.2-8.6 kg.
The dogs were administered four intravenous (IV) treatments: alfaxalone (ALF), alfaxalone+acepromazine and butorphanol (ALF-AB), propofol (PRO) and propofol+AB (PRO-AB). AB doses were standardized. Dogs were anesthetized 5 minutes later by administration of alfaxalone or propofol IV to effect. Arytenoid motion during maximal inspiration and expiration was captured on video before and after IV doxapram (0.25 mg kg). The change in rima glottidis surface area (RGSA) was calculated to measure arytenoid motion. An investigator blinded to the treatment scored laryngeal examination quality.
A 20% increase in RGSA was the minimal arytenoid motion that was detectable. RGSA was significantly less in ALF before doxapram compared with all other treatments. A <20% increase in RGSA was measured in eight of 10 dogs in PRO and in all dogs in ALF before doxapram. After doxapram, RGSA was significantly increased for PRO and ALF; however, 20% of dogs in PRO and 50% of dogs in ALF still had <20% increase in RGSA. A <20% increase in RGSA was measured in five of 10 dogs in PRO-AB and ALF-AB before doxapram. All dogs in PRO-AB and ALF-AB with <20% increase in RGSA before doxapram had ≥20% increase in RGSA after doxapram. Examination quality was significantly better in PRO-AB and ALF-AB.
The use of acepromazine and butorphanol improved the quality of laryngeal examination. Any negative impact on arytenoid motion caused by these premedications was overcome with doxapram. Using either propofol or alfaxalone alone is not recommended for the evaluation of arytenoid motion.
比较阿法沙龙和丙泊酚，以及在使用和不使用乙酰丙嗪和布托啡诺并随后使用多沙普仑的情况下，对犬喉运动及喉部检查质量的影响。
随机、交叉、盲法研究。
10只11 - 13月龄、体重7.2 - 8.6千克的雌性比格犬。
给犬静脉注射四种药物：阿法沙龙（ALF）、阿法沙龙+乙酰丙嗪和布托啡诺（ALF - AB）、丙泊酚（PRO）和丙泊酚+AB（PRO - AB）。AB剂量标准化。5分钟后静脉注射阿法沙龙或丙泊酚使犬麻醉。在静脉注射多沙普仑（0.25毫克/千克）前后，拍摄最大吸气和呼气时杓状软骨运动的视频。计算声门裂表面积（RGSA）的变化以测量杓状软骨运动。一名对治疗不知情的研究者对喉部检查质量进行评分。
RGSA增加20%是可检测到的最小杓状软骨运动。与所有其他治疗相比，多沙普仑给药前ALF组的RGSA显著更小。多沙普仑给药前，PRO组10只犬中有8只、ALF组所有犬的RGSA增加<20%。多沙普仑给药后，PRO组和ALF组的RGSA显著增加；然而，PRO组20%的犬和ALF组50%的犬的RGSA增加仍<20%。多沙普仑给药前，PRO - AB组和ALF - AB组10只犬中有5只的RGSA增加<20%。多沙普仑给药前RGSA增加<20%的PRO - AB组和ALF - AB组所有犬，给药后RGSA增加≥20%。PRO - AB组和ALF - AB组的检查质量显著更好。
使用乙酰丙嗪和布托啡诺可提高喉部检查质量。多沙普仑克服了这些术前用药对杓状软骨运动的任何负面影响。不建议单独使用丙泊酚或阿法沙龙来评估杓状软骨运动。
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