Ranninger Elisabeth, Kantyka Marta, Bektas Rima Nadine
Department of Clinical Diagnostics and Services, Section of Anaesthesiology, Vetsuisse Faculty University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland.
Department of Clinical Veterinary Medicine, Section of Anaesthesiology, Vetsuisse Faculty University of Bern, Hochschulstrasse 6, 3012 Bern, Switzerland.
Animals (Basel). 2020 Mar 22;10(3):530. doi: 10.3390/ani10030530.
Anaesthetic drugs are commonly used during the evaluation of laryngeal function in dogs. The aim of this review was to systematically analyse the literature describing the effects of anaesthetic drugs and doxapram on laryngeal motion in dogs and to determine which drug regime provides the best conditions for laryngeal examination. PubMed, Google Scholar, and EMBASE databases were used for the literature search up to November 2019. Relevant search terms included laryngeal motion, anaesthetic drugs and dogs. Studies were scored based on their level of evidence (LoE), according to the Oxford Centre for Evidence-based Medicine, and the quality was assessed using the risk-of-bias tool and SIGN-checklist. In healthy dogs, premedication before laryngeal examination provided better examination conditions and maintained overall adequate laryngeal motion in 83% of the studies. No difference in laryngeal motion between induction drugs was found in 73% of the studies but the effects in dogs with laryngeal paralysis remain largely unknown. Doxapram increased laryngeal motion in healthy dogs without serious side effects, but intubation was necessary for some dogs with laryngeal paralysis. Methodological characteristics varied considerably between studies, including the technique and timing of evaluation, number of assessors, study design, drug dose, combinations, route and speed of administration.
麻醉药物常用于犬类喉功能评估过程中。本综述的目的是系统分析描述麻醉药物和多沙普仑对犬类喉部运动影响的文献，并确定哪种药物方案能为喉部检查提供最佳条件。截至2019年11月，使用PubMed、谷歌学术和EMBASE数据库进行文献检索。相关检索词包括喉部运动、麻醉药物和犬类。根据牛津循证医学中心的标准，研究依据证据水平（LoE）进行评分，并使用偏倚风险工具和SIGN检查表评估质量。在健康犬中，83%的研究表明，喉部检查前的术前用药能提供更好的检查条件并维持整体足够的喉部运动。73%的研究未发现诱导药物之间在喉部运动方面存在差异，但麻醉性瘫痪犬的相关影响仍大多未知。多沙普仑可增加健康犬的喉部运动且无严重副作用，但部分麻醉性瘫痪犬需要插管。研究之间的方法学特征差异很大，包括评估技术和时间、评估者数量、研究设计、药物剂量、组合、给药途径和速度。
