舌鳞状细胞癌中不寻常的多核巨细胞反应：组织病理学和免疫组织化学特征
Unusual Multinucleated Giant Cell Reaction in a Tongue Squamous Cell Carcinoma: Histopathological and Immunohistochemical Features.
作者信息
Sánchez-Romero Celeste, Carlos Roman, Dantas Soares Ciro, Paes de Almeida Oslei
机构信息
Oral Pathology Section, Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Av. Limeira 901, P.O. Box. 52, Piracicaba, São Paulo, 1314-903, Brazil.
Centro Clínico de Cabeza y Cuello/Hospital Herrera Llerandi, Guatemala, Guatemala.
出版信息
Head Neck Pathol. 2018 Dec;12(4):580-586. doi: 10.1007/s12105-018-0892-8. Epub 2018 Feb 9.
Multinucleated giant cell (MGC) reaction in oral squamous cell carcinoma (OSCC) usually represents a stromal foreign body reaction to keratin from neoplastic epithelial cells. We describe and illustrate by double immunohistochemistry a case of a tongue squamous cell carcinoma (SCC) in a 70-year-old female patient, with a copious MGC reaction not associated to keratin, showing a histopathological pattern not described before. The MGCs were directly associated with neoplastic cells, which are phagocytosed by the MGCs. Immunohistochemistry for CD68, AE1/AE3, CD163, CD11c, RANK, RANK-L, OPG were performed, as well as double staining for CD68 and AE1/AE3 to better illustrate the relationship between MGCs and neoplastic cells. The clinical and biological significance of this pattern of MGC reaction in OSCC needs to be better elucidated.
口腔鳞状细胞癌（OSCC）中的多核巨细胞（MGC）反应通常代表对肿瘤上皮细胞角质形成的基质异物反应。我们通过双重免疫组化描述并展示了一例70岁女性患者的舌鳞状细胞癌（SCC），其有大量与角质无关的MGC反应，呈现出一种此前未描述过的组织病理学模式。MGC与肿瘤细胞直接相关，肿瘤细胞被MGC吞噬。进行了CD68、AE1/AE3、CD163、CD11c、RANK、RANK-L、OPG的免疫组化检测，以及CD68和AE1/AE3的双重染色，以更好地说明MGC与肿瘤细胞之间的关系。这种OSCC中MGC反应模式的临床和生物学意义有待进一步阐明。
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