Teng Dengke, Sui Guoqing, Liu Caimei, Wang Yu, Xia Yongxu, Wang Hui
Department of Ultrasound, China-Japan Union Hospital of Jilin University, Changchun, 130000, Jilin, China.
Department of Interventional Ultrasound, the 208th Hospital of PLA, Changchun, 130000, Jilin, China.
J Cancer Res Clin Oncol. 2018 Apr;144(4):771-779. doi: 10.1007/s00432-018-2607-7. Epub 2018 Feb 9.
To evaluate the safety and efficacy of ultrasound-guided low-power microwave ablation (MWA) for the treatment of papillary thyroid microcarcinoma (PTMC) with a 3-year follow-up.
A total of 21 nodules diagnosed as PTMC from the 15 patients were performed with MWA at a power of 20 W. The images of the nodules were recorded by ultrasound before MWA and 1, 3, 6, 12 months after MWA, and every 6 months thereafter, respectively. The volumes of the nodules were compared before MWA and at each follow-up point after MWA. The volume reduction rate (VRR) of nodules was also calculated.
The mean volume of the nodules was 134.3 ± 129.8 mm initially (the range was 7.4-423.8 mm), which decreased significantly to 2.3 ± 10.5 mm (the range was 0-48.1 mm) of the ablation area (P = 0.000) at the follow-up point of 36 months with a mean VRR as 98.78 ± 5.61% (the range was 74.28-100%). During the follow-up period (the range was 36-48 months), 20 of the 21 nodules were completely absorbed and no recurrent nodule was found.
After a long-term follow-up of 3 years, the low power MWA showed a good safety and efficacy for the treatment of PTMC. In addition to surgery and active surveillance, MWA might be another alternative for patients with PTMC.
评估超声引导下低功率微波消融术（MWA）治疗甲状腺微小乳头状癌（PTMC）的安全性和有效性，并进行3年随访。
对15例患者中诊断为PTMC的21个结节进行20W功率的MWA治疗。在MWA术前及术后1、3、6、12个月以及此后每6个月分别通过超声记录结节图像。比较MWA术前及各随访时间点结节的体积，并计算结节体积缩小率（VRR）。
结节初始平均体积为134.3±129.8mm（范围为7.4 - 423.8mm），在36个月随访时消融区平均体积显著降至2.3±10.5mm（范围为0 - 48.1mm）（P = 0.000），平均VRR为98.78±5.61%（范围为74.28 - 100%）。在随访期（36 - 48个月）内，21个结节中有20个完全吸收，未发现复发结节。
经过3年长期随访，低功率MWA治疗PTMC显示出良好的安全性和有效性。除手术和主动监测外，MWA可能是PTMC患者的另一种选择。
