Tsuchiya T, Sasaki I, Imanura M, Naito H
Nihon Geka Gakkai Zasshi. 1986 Jun;87(6):659-70.
The effect of biliary reconstruction on gastric acid secretion and gut hormones was studied. Canine models undergoing either surgical biliary diversion or jejunal exclusion were compared and the following results were obtained. The acid output from Heidenhain pouch after test meal loading remained in the same levels in the cholecystoduodenostomy (CD) group, the Thiry-Vella's fistula (TVF) group and the cholecystojejunostomy (CJ) group compared to the control group, while it decreased in the cholecystoileostomy group. The integrated gastrin response after test meal loading decreased in the CI group. The integrated total GLI response remained unchanged in the CD group and CJ group, but markedly elevated in the TVF group and CI group. The integrated GIP response decreased in the TVF group and no response was obtained in the CI group. The integrated GI response was almost the same in all groups. In conclusion, gut hormone secretion was found to be affected by jejunal exclusion and most strongly influenced by biliary diversion into the ileum. The present study also suggested that enteroglucagon had enterogastrone effect and that compensating mechanism existed among various gut hormones.
研究了胆道重建对胃酸分泌和肠道激素的影响。比较了接受手术性胆肠转流术或空肠旷置术的犬模型，并获得了以下结果。与对照组相比，胆囊十二指肠吻合术（CD）组、蒂里-韦拉瘘管术（TVF）组和胆囊空肠吻合术（CJ）组在试餐负荷后海登海因袋的胃酸分泌量保持在相同水平，而胆囊回肠吻合术组则下降。CI组试餐负荷后的胃泌素综合反应下降。CD组和CJ组的总胃肠胰多肽（GLI）综合反应保持不变，但TVF组和CI组显著升高。TVF组的葡萄糖依赖性促胰岛素多肽（GIP）综合反应下降，CI组未获得反应。所有组的胃肠综合反应几乎相同。总之，发现肠道激素分泌受空肠旷置影响，且受胆汁转流至回肠的影响最大。本研究还表明，肠高血糖素具有肠抑胃素作用，且各种肠道激素之间存在代偿机制。
