Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences, Northwest University, 229 Taibai North Road, Xi'an 710069 China; Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, 1 Xinsi Road, Xi'an 710038, China.
Department of Occupational and Environmental Health and The Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, China.
Semin Cancer Biol. 2018 Jun;50:21-31. doi: 10.1016/j.semcancer.2018.02.004. Epub 2018 Feb 7.
The epithelial-mesenchymal transition (EMT) is an acknowledged cellular transition process in which epithelial cells acquire mesenchymal-like properties that endow cancer cells with increased migratory and invasive behavior. Forkhead box O (FOXO) proteins have been shown to orchestrate multiple EMT-associated pathways and EMT-related transcription factors (EMT-TFs), thereby modulating the EMT process. The focus of the current review is to evaluate the latest research progress regarding the roles of FOXO proteins in cancer EMT. First, a brief overview of the EMT process in cancer and a general background on the FOXO family are provided. Next, we present the interactions between FOXO proteins and multiple EMT-associated pathways during malignancy development. Finally, we propose several novel potential directions for future research. Collectively, the information compiled herein should serve as a comprehensive repository of information on this topic and should aid in the design of additional studies and the future development of FOXO proteins as therapeutic targets.
上皮-间充质转化（EMT）是一种公认的细胞转化过程，在此过程中，上皮细胞获得间充质样特性，赋予癌细胞更高的迁移和侵袭行为。叉头框 O（FOXO）蛋白已被证明可以协调多种 EMT 相关途径和 EMT 相关转录因子（EMT-TFs），从而调节 EMT 过程。本综述的重点是评估 FOXO 蛋白在癌症 EMT 中的作用的最新研究进展。首先，简要概述癌症中的 EMT 过程和 FOXO 家族的一般背景。接下来，我们介绍了 FOXO 蛋白与恶性肿瘤发生过程中多种 EMT 相关途径之间的相互作用。最后，我们提出了未来研究的几个新的潜在方向。总的来说，本文中汇集的信息应该作为该主题的综合信息库，并有助于设计更多的研究和未来将 FOXO 蛋白作为治疗靶点。
