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E6 and E7 gene silencing results in decreased methylation of tumor suppressor genes and induces phenotype transformation of human cervical carcinoma cell lines.E6和E7基因沉默导致肿瘤抑制基因甲基化减少，并诱导人宫颈癌细胞系的表型转化。
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Upregulation of long non‑coding RNA CCEPR is associated with poor prognosis and contributes to the progression of ovarian cancer through regulating the Wnt/β‑catenin signaling pathway.长链非编码 RNA CCEPR 的上调与不良预后相关，并通过调节 Wnt/β-连环蛋白信号通路促进卵巢癌的进展。
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HPV16 oncogenes E6 or/and E7 may influence the methylation status of RASSFIA gene promoter region in cervical cancer cell line HT-3.人乳头瘤病毒16型癌基因E6或/和E7可能影响宫颈癌细胞系HT-3中RASSFIA基因启动子区域的甲基化状态。
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Coordinated action of human papillomavirus type 16 E6 and E7 oncoproteins on competitive endogenous RNA (ceRNA) network members in primary human keratinocytes.人乳头瘤病毒 16 型 E6 和 E7 癌蛋白在原代人角质形成细胞中的竞争性内源性 RNA（ceRNA）网络成员上的协调作用。
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本文引用的文献

1
The multidimensional mechanisms of long noncoding RNA function.长非编码 RNA 功能的多维机制。
Genome Biol. 2017 Oct 31;18(1):206. doi: 10.1186/s13059-017-1348-2.
2
How do lncRNAs regulate transcription?长非编码 RNA 如何调控转录？
Sci Adv. 2017 Sep 27;3(9):eaao2110. doi: 10.1126/sciadv.aao2110. eCollection 2017 Sep.
3
Increased expression of long non-coding RNA CCEPR is associated with poor prognosis and promotes tumorigenesis in urothelial bladder carcinoma.长链非编码RNA CCEPR的表达增加与预后不良相关，并促进膀胱尿路上皮癌的肿瘤发生。
Oncotarget. 2017 Jul 4;8(27):44326-44334. doi: 10.18632/oncotarget.17872.
4
Long non-coding RNA CCHE1 overexpression predicts a poor prognosis for cervical cancer.长链非编码RNA CCHE1的过表达预示着宫颈癌的预后不良。
Eur Rev Med Pharmacol Sci. 2017 Feb;21(3):479-483.
5
Modulation of microRNA-mRNA Target Pairs by Human Papillomavirus 16 Oncoproteins.人乳头瘤病毒16型癌蛋白对微小RNA-信使核糖核酸靶对的调控
mBio. 2017 Jan 3;8(1):e02170-16. doi: 10.1128/mBio.02170-16.
6
Linking Long Noncoding RNA Localization and Function.连接长非编码 RNA 的定位和功能。
Trends Biochem Sci. 2016 Sep;41(9):761-772. doi: 10.1016/j.tibs.2016.07.003. Epub 2016 Aug 4.
7
Long noncoding RNA CCHE1 indicates a poor prognosis of hepatocellular carcinoma and promotes carcinogenesis via activation of the ERK/MAPK pathway.长链非编码 RNA CCHE1 提示肝细胞癌预后不良，并通过激活 ERK/MAPK 通路促进癌变。
Biomed Pharmacother. 2016 Oct;83:450-455. doi: 10.1016/j.biopha.2016.06.056. Epub 2016 Jul 16.
8
Systematic gene microarray analysis of the lncRNA expression profiles in human uterine cervix carcinoma.人子宫颈癌lncRNA表达谱的系统基因芯片分析
Biomed Pharmacother. 2015 May;72:83-90. doi: 10.1016/j.biopha.2015.04.010. Epub 2015 Apr 17.
9
Long noncoding RNA CCHE1 promotes cervical cancer cell proliferation via upregulating PCNA.长链非编码RNA CCHE1通过上调增殖细胞核抗原促进宫颈癌细胞增殖。
Tumour Biol. 2015 Sep;36(10):7615-22. doi: 10.1007/s13277-015-3465-4. Epub 2015 Apr 29.
10
Long non-coding RNAs in cancer: implications for personalized therapy.癌症中的长链非编码RNA：对个性化治疗的启示
Cell Oncol (Dordr). 2015 Feb;38(1):17-28. doi: 10.1007/s13402-014-0180-x. Epub 2014 Aug 12.

宫颈癌细胞表达的 PCNA 调控（CCEPR）长非编码 RNA 的表达受人类乳头瘤病毒 E6 蛋白驱动，并独立于 PCNA 调节细胞增殖。

Expression of the cervical carcinoma expressed PCNA regulatory (CCEPR) long noncoding RNA is driven by the human papillomavirus E6 protein and modulates cell proliferation independent of PCNA.

机构信息

Biochemistry Program, Sackler School of Graduate Biomedical Sciences and Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA 02111, United States.

Biochemistry Program, Sackler School of Graduate Biomedical Sciences and Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA 02111, United States.

出版信息

Virology. 2018 May;518:8-13. doi: 10.1016/j.virol.2018.01.031. Epub 2018 Feb 7.

DOI:10.1016/j.virol.2018.01.031
PMID:29427865
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5911229/
Abstract

Modulation of expression of noncoding RNAs is an important aspect of the oncogenic activities of high-risk human papillomavirus (HPV) E6 and E7 proteins. While HPV E6/E7-mediated alterations of microRNAs (miRNAs) has been studied in detail there are fewer reports on HPV-mediated dysregulation of long noncoding RNAs (lncRNAs). The cervical carcinoma expressed PCNA regulatory (CCEPR) lncRNA is highly expressed in cervical cancers and expression correlates with tumor size and patient outcome. We report that CCEPR is a nuclear lncRNA and that HPV16 E6 oncogene expression causes increased CCEPR expression through a mechanism that is not directly dependent on TP53 inactivation. CCEPR depletion in cervical carcinoma cell lines reduces viability, while overexpression enhances viability. In contrast to what was published and inspired its designation, there is no evidence for PCNA mRNA stabilization, and hence CCEPR likely functions through a different mechanism.

摘要

非编码 RNA 的表达调控是高危型人乳头瘤病毒（HPV）E6 和 E7 蛋白致癌活性的一个重要方面。虽然 HPV E6/E7 介导的 microRNAs（miRNAs）改变已经得到了详细研究，但关于 HPV 介导的长非编码 RNA（lncRNA）失调的报道较少。宫颈癌细胞表达的 PCNA 调控（CCEPR）lncRNA 在宫颈癌中高度表达，其表达与肿瘤大小和患者预后相关。我们报告 CCEPR 是一种核 lncRNA，HPV16 E6 癌基因表达通过一种不直接依赖于 TP53 失活的机制导致 CCEPR 表达增加。在宫颈癌细胞系中耗尽 CCEPR 会降低细胞活力，而过表达则会增强细胞活力。与已发表的并启发其命名的内容相反，没有证据表明 PCNA mRNA 稳定，因此 CCEPR 可能通过不同的机制发挥作用。