Department de Ciències Fisiològiques, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, 08907 Hospitalet de Llobregat, Catalonia, Spain; Institute of Neuroscience, Universitat de Barcelona, Catalonia, Spain; Institut d'Investigació Biomèdica de Bellvitge, IDIBELL, 08907 Hospitalet de Llobregat, Catalonia, Spain.
Department de Ciències Fisiològiques, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, 08907 Hospitalet de Llobregat, Catalonia, Spain.
Neurotoxicology. 2018 May;66:204-212. doi: 10.1016/j.neuro.2018.02.003. Epub 2018 Feb 8.
Physiological methods that can be similarly recorded in humans and animals have a major role in sensory toxicology, as they provide a bridge between human sensory perception data and the molecular and cellular data obtained in animal studies. Vestibular toxicity research lags well behind other sensory systems in many aspects, including the availability of methods for functional assessment in animals that could be robustly translated to human significance. Here we review the methods available for the assessment of vestibular function in both humans and laboratory animals, with an emphasis on their similarity or divergence, to highlight their potential utility for the predictive assessment of vestibular toxicity.
在感觉毒理学中，能够在人和动物中进行类似记录的生理学方法具有重要作用，因为它们在人类感觉感知数据和在动物研究中获得的分子和细胞数据之间架起了桥梁。在许多方面，前庭毒性研究都远远落后于其他感觉系统，包括用于动物功能评估的方法，这些方法在人类中具有重要意义，但还没有得到广泛应用。本文综述了人类和实验动物前庭功能评估的方法，重点讨论了它们的相似性或差异性，以突出它们在预测前庭毒性方面的潜在应用价值。
