Materials Chemistry Research Center, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002,Thailand.
Materials Chemistry Research Center, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002,Thailand.
Spectrochim Acta A Mol Biomol Spectrosc. 2018 May 5;196:7-15. doi: 10.1016/j.saa.2018.01.062. Epub 2018 Feb 20.
A fluorescent sensor based on thioglycolic acid-capped cadmium sulfide quantum dots (TGA-CdS QDs) has been designed for the sensitive and selective detection of dopamine (DA). In the presence of dopamine (DA), the addition of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and N-hydroxysuccinimide (NHS) activates the reaction between the carboxylic group of the TGA and the amino group of dopamine to form an amide bond, quenching the fluorescence of the QDs. The fluorescence intensity of TGA-CdS QDs can be used to sense the presence of dopamine with a limit of detection of 0.68μM and a working linear range of 1.0-17.5μM. This sensor system shows great potential application for dopamine detection in dopamine drug samples and for future easy-to-make analytical devices.
基于巯基乙酸（TGA）修饰的硫化镉量子点（TGA-CdS QDs）的荧光传感器被设计用于灵敏和选择性检测多巴胺（DA）。在多巴胺（DA）存在的情况下，加入 1-乙基-3-（3-二甲基氨基丙基）碳二亚胺（EDC）和 N-羟基琥珀酰亚胺（NHS）激活 TGA 的羧基与多巴胺的氨基之间的反应，形成酰胺键，从而猝灭 QDs 的荧光。TGA-CdS QDs 的荧光强度可用于检测多巴胺的存在，检测限为 0.68μM，工作线性范围为 1.0-17.5μM。该传感器系统在多巴胺药物样品中检测多巴胺以及未来易于制作的分析设备方面具有很大的应用潜力。
